40941-53-5

Basic information

• Product Name: 7-chloro-4-methylquinoline
• Synonyms: 7-chloro-4-methylquinoline;4-Methyl-7-chloroquinoline
• CAS NO: 40941-53-5
• Molecular Formula: C₁₀H₈ClN
• Molecular Weight: 177.63022
• EINECS: 255-147-5
• Mol File: 40941-53-5.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 294.2°Cat760mmHg
• Flash Point: 159.6°C
• Appearance: /
• Density: 1.225g/cm³
• Vapor Pressure: 0.00289mmHg at 25°C
• Refractive Index: 1.634
• CAS DataBase Reference: 7-chloro-4-methylquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 7-chloro-4-methylquinoline(40941-53-5)
• EPA Substance Registry System: 7-chloro-4-methylquinoline(40941-53-5)

Safety Data

• Hazardous Substances Data: 40941-53-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H8ClN/c1-7-4-5-12-10-6-8(11)2-3-9(7)10/h2-6H,1H3

Upstream product

• 86-98-6 4,7-dichloroquinoline 
• 75-16-1 methylmagnesium bromide 
• 18826-95-4 1.3-butanediol 
• 108-42-9 3-chloro-aniline 
• 141-85-5 3-chloroaniline hydrochloride 
• 78-94-4 methyl vinyl ketone 
• 121714-78-1 iron(III) chloride hexahydrate 
• 6607-66-5 1,3,3-trimethoxybutane 

Downstream Products

• 13337-66-1 7-chloroquinoline-4-carboxylic acid 
• 476473-27-5 1-[2-(7-Chloro-quinolin-4-yl)-1-(6-methyl-pyridin-2-yl)-eth-(E)-ylideneamino]-pyrrolidin-2-one 
• 476473-26-4 1-[2-(7-Chloro-quinolin-4-yl)-1-pyridin-2-yl-eth-(E)-ylideneamino]-pyrrolidin-2-one 
• 476472-19-2 2-(7-chloro-quinoline-4-yl)-1-(6-methyl-pyridin-2-yl)-ethanone 
• 476472-18-1 2-(7-chloro-quinolin-4-yl)-1-pyridin-2-yl-ethanone 

Relevant articles and documents

Metal-Free Chemoselective Oxidation of 4-Methylquinolines into Quinoline-4-Carbaldehydes

A convenient protocol for the synthesis of quinoline-4-carbaldehydes via chemoselective oxidation of 4-methylquinolines using hypervalent iodine(III) reagents as oxidant is described. This method highlights metal-free and mild reaction conditions, nice yield, good functional group tolerance, and high chemoselectivity.

Dearomative Photocatalytic Construction of Bridged 1,3-Diazepanes

The construction of diverse sp3-rich skeletal ring systems is of importance to drug discovery programmes and natural product synthesis. Herein, we report the photocatalytic construction of 2,7-diazabicyclo[3.2.1]octanes (bridged 1,3-diazepanes) via a reductive diversion of the Minisci reaction. The fused tricyclic product is proposed to form via radical addition to the C4 position of 4-substituted quinoline substrates, with subsequent Hantzsch ester-promoted reduction to a dihydropyridine intermediate which undergoes in situ two-electron ring closure to form the bridged diazepane architecture. A wide scope of N-arylimine and quinoline derivatives was demonstrated and good efficiency was observed in the construction of sterically congested all-carbon quaternary centers. Computational and experimental mechanistic studies provided insights into the reaction mechanism and observed regioselectivity/diastereoselectivity.

Quinolines synthesis by reacting 1,3-butanediol with anilines in the presence of iron catalysts

2-, 4-, 6-, 7-, and 8-substituted quinolines were synthesized in 78–95% yield by the reaction of 1,3- butanediol with anilines in the presence of iron catalysts in carbon tetrachloride.