40957-99-1

Basic information

• Product Name: Medioresil
• Synonyms: Medioresil;Medioresinol
• CAS NO: 40957-99-1
• Molecular Formula: C₂₁H₂₄O₇
• Molecular Weight: 388.41106
• Mol File: 40957-99-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 170-172 °C(Solv: methanol (67-56-1))
• Boiling Point: 575.7°C at 760 mmHg
• Flash Point: 302°C
• Appearance: /
• Density: 1.284g/cm³
• Vapor Pressure: 7.43E-14mmHg at 25°C
• Refractive Index: 1.587
• PKA: 9.84±0.35(Predicted)
• CAS DataBase Reference: Medioresil(CAS DataBase Reference)
• NIST Chemistry Reference: Medioresil(40957-99-1)
• EPA Substance Registry System: Medioresil(40957-99-1)

Safety Data

• Hazardous Substances Data: 40957-99-1(Hazardous Substances Data)

Usage

General Description

Medioresil is a commercial name for a chemical compound composed of a mixture of medium chain triglycerides, silicone oil, and cetyl dimethicone. The medium chain triglycerides are derived from coconut oil and have emollient properties, while the silicone oil and cetyl dimethicone act as skin conditioning agents. Medioresil is commonly used in cosmetic and personal care products such as lotions, creams, and sunscreens due to its ability to moisturize and soften the skin, as well as provide a smooth and silky feel to the products. Additionally, the combination of these ingredients helps to improve the spreadability and stability of formulations, making it a popular choice for skincare products.

InChI:InChI=1/C21H24O7/c1-24-16-6-11(4-5-15(16)22)20-13-9-28-21(14(13)10-27-20)12-7-17(25-2)19(23)18(8-12)26-3/h4-8,13-14,20-23H,9-10H2,1-3H3/t13-,14-,20+,21+/m0/s1

Upstream product

• 458-35-5 coniferol 
• 20675-96-1 Syringenin 
• 6527-32-8 4-(benzyloxy)-3,5-dimethoxybenzaldehyde 
• 123195-63-1 4-benzyloxy-3-methoxybenzaldehyde-bis-phenylthioacetal 
• 1428768-22-2 2,6-dimethoxy-4-[(1S,3aR,4S,6aR)-4-(3-methoxy-4-{[(2Z)-2-methylbut-2-enoyl]oxy}phenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]phenyl (2Z)-2-methylbut-2-enoate 
• 97399-82-1 hedyotol-C 
• 97400-05-0 hedyotol-C tetraacetate 
• 67-64-1 acetone 
• 99633-12-2 medioresinol-4″-β-glucoside 

Downstream Products

• 136051-42-8 (7'R,8'S,8S)-5-methoxylariciresinol triacetate 
• 136051-41-7 (+)-5'-methoxylariciresinol 

Relevant articles and documents

Dirigent Proteins Guide Asymmetric Heterocoupling for the Synthesis of Complex Natural Product Analogues

Phenylpropanoids are a class of abundant building blocks found in plants and derived from phenylalanine and tyrosine. Phenylpropanoid polymerization leads to the second most abundant biopolymer lignin while stereo- and site-selective coupling generates an array of lignan natural products with potent biological activity, including the topoisomerase inhibitor and chemotherapeutic etoposide. A key step in etoposide biosynthesis involves a plant dirigent protein that promotes selective dimerization of coniferyl alcohol, a common phenylpropanoid, to form (+)-pinoresinol, a critical C2 symmetric pathway intermediate. Despite the power of this coupling reaction for the elegant and rapid assembly of the etoposide scaffold, dirigent proteins have not been utilized to generate other complex lignan natural products. Here, we demonstrate that dirigent proteins from Podophyllum hexandrum in combination with a laccase guide the heterocoupling of natural and synthetic coniferyl alcohol analogues for the enantioselective synthesis of pinoresinol analogues. This route for complexity generation is remarkably direct and efficient: three new bonds and four stereocenters are produced from two different achiral monomers in a single step. We anticipate our results will enable biocatalytic routes to difficult-to-access non-natural lignan analogues and etoposide derivatives. Furthermore, these dirigent protein and laccase-promoted reactions of coniferyl alcohol analogues represent new regio- and enantioselective oxidative heterocouplings for which no other chemical methods have been reported.

New lignans from the aerial parts of Rudbeckia laciniata

Three new furofuran lignans, (+)-4,4′-O-diangeloylpinoresinol (1), (+)-4,4′-O-diangeloylmedioresinol (2), and (+)-4,4′-O- diangeloylsyringaresinol (3), together with the known compound (+)-syringaresinol, were isolated from the MeOH extract of Rudbeckia l

The constituents of Eucommia ulmoides OLIV. II. Isolation and structures of three new lignan glycosides

-