41018-73-9

Basic information

• Product Name: (4-CHLORO-PHENYL)-(4-METHOXY-PHENYL)-AMINE
• Synonyms: (4-CHLORO-PHENYL)-(4-METHOXY-PHENYL)-AMINE;4-chloro-N-(4-methoxyphenyl)aniline
• CAS NO: 41018-73-9
• Molecular Formula: C₁₃H₁₂ClNO
• Molecular Weight: 233.69348
• Mol File: 41018-73-9.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4-CHLORO-PHENYL)-(4-METHOXY-PHENYL)-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (4-CHLORO-PHENYL)-(4-METHOXY-PHENYL)-AMINE(41018-73-9)
• EPA Substance Registry System: (4-CHLORO-PHENYL)-(4-METHOXY-PHENYL)-AMINE(41018-73-9)

Safety Data

• Hazardous Substances Data: 41018-73-9(Hazardous Substances Data)

Usage

Description

(4-CHLORO-PHENYL)-(4-METHOXY-PHENYL)-AMINE is a chemical compound with a molecular formula C13H12ClNO. It is an aniline derivative that consists of a chlorophenyl group and a methoxyphenyl group connected to an amine group. (4-CHLORO-PHENYL)-(4-METHOXY-PHENYL)-AMINE is versatile and has potential applications in various industries, including organic chemistry, medicine, and material science, due to its unique chemical structure and properties.

Uses

Used in Pharmaceutical Industry:
(4-CHLORO-PHENYL)-(4-METHOXY-PHENYL)-AMINE is used as a building block in the synthesis of pharmaceuticals for its potential role in creating new medicinal compounds.
Used in Agrochemical Industry:
(4-CHLORO-PHENYL)-(4-METHOXY-PHENYL)-AMINE is used as a precursor in the development of agrochemicals, contributing to the creation of new products for agricultural applications.
Used in Organic Chemistry:
(4-CHLORO-PHENYL)-(4-METHOXY-PHENYL)-AMINE is used as a reagent or intermediate in various organic chemical reactions, such as nucleophilic aromatic substitution, to produce a range of organic compounds.
Used in Material Science:
(4-CHLORO-PHENYL)-(4-METHOXY-PHENYL)-AMINE is utilized in the field of material science for its potential to contribute to the development of new materials with specific properties.

Upstream product

• 106-39-8 bromochlorobenzene 
• 100-17-4 para-methoxynitrobenzene 
• 696-62-8 para-iodoanisole 
• 106-47-8 4-chloro-aniline 
• 5720-07-0 4-methoxyphenylboronic acid 
• 100-00-5 4-chlorobenzonitrile 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 1679-18-1 4-Chlorophenylboronic acid 
• 104-94-9 4-methoxy-aniline 
• 637-87-6 1-Chloro-4-iodobenzene 
• 51-66-1 4-methoxyacetanilide 
• 1208-86-2 N-(4-methoxyphenyl)phenylamine 
• 7647-01-0 hydrogenchloride 
• 60-29-7 diethyl ether 

Downstream Products

• 61298-20-2 N-acetoacetyl-4-chloro-4'-methoxydiphenylamine 
• 101-64-4 Variamin Blau 
• 1581259-58-6 ethyl 2-[N-(4-chlorophenyl)-N-(4-methoxyphenyl)sulfamoyl]acetate 
• 1581259-17-7 ethyl 2-[N-(4-chlorophenyl)-N-(4-methoxyphenyl)sulfamoyl]-2-diazoacetate 
• 1581259-35-9 ethyl 5-chloro-1-(4-methoxyphenyl)-1,3-dihydrobenzo[c]isothiazole-3-carboxylate 2,2-dioxide 
• 1581259-37-1 ethyl 1-(4-chlorophenyl)-5-methoxy-1,3-dihydrobenzo[c]isothiazole-3-carboxylate 2,2-dioxide 

Relevant articles and documents

Fe-MIL-101 modified by isatin-Schiff-base-Co: a heterogeneous catalyst for C-C, C-O, C-N, and C-P cross coupling reactions

A metal-organic framework functionalized with a cobalt-complex is preparedviapost-synthetic modification of Fe-MIL-101-NH2. Initially, Fe-MIL-101-NH2reacted with isatin to produce Fe-MIL-101-isatin-Schiff-base, which can anchor the cobalt by the addition of cobalt acetate. The resulting MOF-Co catalyst is characterized by employing multiple techniques. This new modified MOF acts as a heterogeneous and recyclable catalyst for efficient Ullmann, Buchwald-Hartwig, Hirao, Hiyama and Mizoroki-Heck cross-coupling reactions of several aryl halides/phenylboronic acid/phenyltosylate with phenols, anilines/heterocyclic amines, triethyl phosphite, triethoxyphenylsilane and alkenes and generates the expected coupling products in good to high yields.

Visible-Light- And PPh3-Mediated Direct C-N Coupling of Nitroarenes and Boronic Acids at Ambient Temperature

We present here a metal-free, visible-light- and triphenylphosphine-mediated intermolecular, reductive amination between nitroarenes and boronic acids at ambient temperature without any photocatalyst. Mechanistically, a slow reduction of nitroarenes to a nitroso and, finally, a nitrene intermediate occurs that leads to the amination product with concomitant 1,2-aryl/-alkyl migration from a boronate complex. A wide range of nitroarenes underwent C-N coupling with aryl-/alkylboronic acids providing high yields.

Light-Promoted C–N Coupling of Aryl Halides with Nitroarenes

A photochemical C–N coupling of aryl halides with nitroarenes is demonstrated for the first time. Catalyzed by a NiII complex in the absence of any external photosensitizer, readily available nitroarenes undergo coupling with a variety of aryl halides, providing a step-economic extension to the widely used Buchwald–Hartwig C–N coupling reaction. The method tolerates coupling partners with steric-congestion and functional groups sensitive to bases and nucleophiles. Mechanistic studies suggest that the reaction proceeds via the addition of an aryl radical, generated from a NiI/NiIII cycle, to a nitrosoarene intermediate.