41018-86-4

Basic information

• Product Name: 2,3-Dimethyl-7-nitroindole
• Synonyms: 2,3-dimethyl-7-nitro-indol;7-Nitro-2,3-dimethylindole;2,3-Dimethyl-7-nitroindole,95%;2,3-DIMETHYL-7-NITRO-1H-INDOLE;2,3-DIMETHYL-7-NITROINDOLE
• CAS NO: 41018-86-4
• Molecular Formula: C₁₀H₁₀N₂O₂
• Molecular Weight: 190.2
• EINECS: 240-669-8
• Product Categories: Indole
• Mol File: 41018-86-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 160-165 °C
• Boiling Point: 325.7°C (rough estimate)
• Flash Point: 181.9 °C
• Appearance: light yellow powder
• Density: 1.2167 (rough estimate)
• Vapor Pressure: 1.49E-05mmHg at 25°C
• Refractive Index: 1.6300 (estimate)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Water Solubility: negligible
• CAS DataBase Reference: 2,3-Dimethyl-7-nitroindole(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Dimethyl-7-nitroindole(41018-86-4)
• EPA Substance Registry System: 2,3-Dimethyl-7-nitroindole(41018-86-4)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• Hazardous Substances Data: 41018-86-4(Hazardous Substances Data)

Usage

Chemical Properties

orange to dark brown powder or needles

InChI:InChI=1/C10H10N2O2/c1-6-7(2)11-10-8(6)4-3-5-9(10)12(13)14/h3-5,11H,1-2H3

Upstream product

• 6293-87-4 o-nitrophenylhydrazine hydrochloride 
• 78-93-3 butanone 

Downstream Products

• 101832-73-9 7-amino-2,3-diemethylindole 
• 119014-20-9 1,2,3-trimethyl-6,7-diphenyl-1,8-dihydro-pyrrolo[3,2-g]indole 

Relevant articles and documents

Efficient and straightforward synthesis of tetrahydrocarbazoles and 2,3-dimethyl indoles catalyzed by CAN

A simple protocol was established to synthesize 2,3-dialkyl indoles and various tetrahydrocarbazoles via Fischer indole synthesis. This method uses ceric ammonium nitrate as a catalyst for the Fischer indole synthesis with substituted phenyl hydrazine hydrochlorides and 2-butanone, phenyl propanal, and cyclohexanone. This process is a practical synthetic method for the preparation of various 2,3-disubstituted alkyl indoles and tetrahydrocarbazoles. Copyright Taylor & Francis Group, LLC.

Bismuth nitrate promoted fischer indole synthesis: A simple and convenient approach for the synthesis of alkyl indoles

A novel one-pot fisher indole synthesis approach has been developed by using bismuth nitrate as a catalyst. Yields around 90-95% were obtained after reaction in methanol at reflux temperature in 20-40 min. Apart from the mild reaction conditions of the process and its excellent results, the simplicity of product isolation and the possibility to recycle the bismuth nitrate offers a significant advantage.