41036-01-5

Basic information

• Product Name: 4-(2-hydroxyethyl)morpholin-3-one
• Synonyms: 4-(2-hydroxyethyl)morpholin-3-one
• CAS NO: 41036-01-5
• Molecular Formula: C₆H₁₁NO₃
• Molecular Weight: 145.16
• Mol File: 41036-01-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 340.746°C at 760 mmHg
• Flash Point: 159.878°C
• Appearance: /
• Density: 1.208g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.488
• PKA: 14.39±0.10(Predicted)
• CAS DataBase Reference: 4-(2-hydroxyethyl)morpholin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-hydroxyethyl)morpholin-3-one(41036-01-5)
• EPA Substance Registry System: 4-(2-hydroxyethyl)morpholin-3-one(41036-01-5)

Safety Data

• Hazardous Substances Data: 41036-01-5(Hazardous Substances Data)

Usage

General Description

4-(2-hydroxyethyl)morpholin-3-one, also known as HEMO, is a chemical compound that belongs to the family of morpholine derivatives. It is a white crystalline solid with a molecular formula of C6H11NO2 and a molecular weight of 129.16 g/mol. HEMO is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals, as well as a building block for the production of polymers and resins. It is also utilized as a corrosion inhibitor and a chelating agent in various industrial processes. Additionally, HEMO has applications in the formulation of coatings, adhesives, and sealants. Due to its versatile properties and wide-ranging applications, 4-(2-hydroxyethyl)morpholin-3-one is an important chemical compound in the chemical and pharmaceutical industries.

InChI:InChI=1/C6H11NO3/c8-3-1-7-2-4-10-5-6(7)9/h8H,1-5H2

Upstream product

• 622-40-2 2-(morpholin-4-yl)ethanol 
• 96-34-4 methyl chloroacetate 
• 111-42-2 2,2'-iminobis[ethanol] 
• 892871-54-4 4-(2-(benzyloxy)ethyl)morpholin-3-one 
• 186294-83-7 2-(3-oxomorpholino)ethyl chloroacetate 
• 186294-80-4 Chloro-acetic acid 2-[(2-chloro-acetyl)-(2-hydroxy-ethyl)-amino]-ethyl ester 

Downstream Products

• 79874-76-3 3-(4-propyl-heptyl)-4-(2-hydroxyethyl)-morpholine 
• 98092-92-3 rac-4-(2-hydroxyethyl)-3-(4-propylheptyl) morpholine hydrochloride 
• 205193-82-4 4-(4-chloro-2-fluoroanilino)-6-methoxy-7-(2-(3-oxomorpholino)ethoxy)quinazoline hydrochloride 
• 205193-97-1 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(2-(3-oxomorpholino)ethoxy)quinazoline hydrochloride 

Relevant articles and documents

MODULATORS OF G-PROTEIN COUPLED RECEPTORS

This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt and/or hydrate and/or prodrug of the compound) that modulate (e.g., agonize or partially agonize or antagonize) glucagon?like peptide?1 receptor ("GLP?1R") and/or the gastric inhibitory polypeptide receptor ("GIPR"). The chemical entities are useful, e.g., for treating a subject (e.g., a human) having a disease, disorder, or condition in which modulation (e.g., agonism, partial agonism or antagonism) of GLP?1R and/or GIPR activities is benficial for the treatment or prevention of the underlying pathology and/or symptoms and/or progression of the disease, disorder, or condition. In some embodiments, the modulation results in an enhancment of (e.g., an increase in) existing levels (e.g., normal or below normal levels) of GLP?1R and/or GIPR activity (e.g., signaling). In some embodiments, the chemical entities described herein further modulate (e.g., attenuate, uncouple) -arrestin signaling relative to what is observed with the native ligand. This disclosure also features compositions as well as other methods of using and making the said chemical entities.

METHOD FOR THE MANUFACTURING OF 2-(3-(ALKYL AND ALKENYL)MORPHOLINO)-ETHAN-1-OLS

The present invention relates to a method for the manufacture of 2-(3-(alkyl or alkenyl)morpholino)-ethan-1-ols by reduction of 8a-(alkyl and alkenyl)hexahydrooxazolo[2,3-c][1,4]oxazines encompassing a process for producing 2-(3-(4-propylheptyl)morpholino)ethan-1-ol with the INN name delmopinol. The invention also relates to 1-chloro-4-propylhept-3-ene, 1-iodo-4-propylhept-3-ene, 8a-(4-5 propylheptyl)hexahydrooxazolo[2,3-c][1,4]oxazine, 8a-(4-propylhept-3-en-1-yl)hexahydrooxazolo[2,3-c][1,4]oxazine and 2-(3-(4-propylhept-3-en-1-yl)morpholino)ethan-1-ol which are intermediates in the delmopinol process.

THIAZOLOPYRIDINONE DERIVATES AS MCH RECEPTOR ANTAGONISTS

The present invention relates to a melanin concentrating hormone antagonist compound of formula (I); wherein w, R1, q, p, R2, t, Ar1, L1, R3 and R4 are as defined, or a pharmaceutically acceptable salt, solvate, or enantiomer thereof useful in the treatment, prevention or amelioration of symptoms associated with obesity and related diseases.