41057-04-9

Basic information

• Product Name: 3-Thiophenecarboxaldehyde, 2-nitro- (6CI,9CI)
• Synonyms: 3-Thiophenecarboxaldehyde, 2-nitro- (6CI,9CI);2-Nitro-3-thiophenecarboxaldehyde;3-Formyl-2-nitrothiophene
• CAS NO: 41057-04-9
• Molecular Formula: C₅H₃NO₃S
• Molecular Weight: 157.14722
• Product Categories: ALDEHYDE
• Mol File: 41057-04-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 55.5-56.5℃ (ligroine ethyl ether (1:1))
• Appearance: /
• CAS DataBase Reference: 3-Thiophenecarboxaldehyde, 2-nitro- (6CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Thiophenecarboxaldehyde, 2-nitro- (6CI,9CI)(41057-04-9)
• EPA Substance Registry System: 3-Thiophenecarboxaldehyde, 2-nitro- (6CI,9CI)(41057-04-9)

Safety Data

• Hazardous Substances Data: 41057-04-9(Hazardous Substances Data)

Upstream product

• 857244-68-9 acetic acid-(2-nitro-[3]thienylmethyl ester) 
• 71533-51-2 3-bromomethyl-2-nitrothiophene 
• 616-44-4 3-Methylthiophene 
• 98277-70-4 thiophen-3-ylmethyl acetate 
• 32059-75-9 3-methyl-2-nitrothiophene 
• 113388-38-8 3-(dichloromethyl)-2-nitrothiophene 
• 98027-62-4 3-hydroxymethyl-2-nitro-thiophene 

Downstream Products

• 75754-81-3 3t-(2-nitro-[3]thienyl)-acrylic acid 
• 100114-28-1 2-nitro-thiophene-3-carbaldehyde semicarbazone 
• 100114-26-9 2-nitro-thiophene-3-carbaldehyde thiosemicarbazone 
• 96460-83-2 3t-(2-nitro-[3]thienyl)-1-phenyl-propenone 
• 100727-81-9 3-hydroxy-3-(2-nitro-[3]thienyl)-1-phenyl-propan-1-one 
• 103853-40-3 2-nitro-thiophene-3-carbaldehyde-phenylhydrazone 
• 41056-82-0 2-nitrothiophene-3-carboxime 
• 179231-32-4 6,8-Dimethyl-5-oxo-4,5-dihydro-thieno<2,3-c><2,7>naphthyridin-9-carbonsaeuremethylester 
• 179231-36-8 5-Chlor-6,8-dimethyl-thieno<2,3-c><2,7>naphthyridin-9-carbonsaeuremethylester 
• 179231-34-6 6,8-Dimethyl-5-oxo-4,5-dihydro-thieno<2,3-h><1,6>naphthyridin-7-carbonsaeuremethylester 
• 179231-38-0 5-Chlor-6,8-dimethyl-thieno<2,3-h><1,6>naphthyridin-7-carbonsaeuremethylester 
• 179231-26-6 2,6-Dimethyl-4-(2-nitro-3-thienyl)-pyridin-3,5-dicarbonsaeuredimethylester 
• 179231-28-8 4,6-Dimethyl-2-(2-nitro-3-thienyl)-pyridin-3,5-dicarbonsaeuredimethylester 
• 100037-80-7 6-phenyl-thieno[2,3-b]pyridine 

Relevant articles and documents

NOVEL ANTIMALARIA AGENT CONTAINING HETEROCYCLIC COMPOUND

Disclosed is an antimalarial agent containing a compound represented by the formula: [wherein A1 represents a 3-pyridyl group that may have a substituent, a 6-quinolyl group that may have a substituent, or the like; X1 represents a group represented by the formula -C(=O)-NH- or the like; E represents a furyl group, a thienyl group or a phenyl group; with the proviso that A1 may have one to three substituents, and E has one of two substituents] or a salt thereof or hydrates thereof.

Five membered ring analogues of nifedipine - Part 1: 2-Nitro-3-furanecarbaldehyde and 2-nitro-3-thiophenecarbaldehyde in the Hantzsch pyridine synthesis

The heterocyclic aldehydes 4 in the Hantzsch pyridine synthesis afforded dependent on the choosen variation, either the 1,4-dihydropyridines (DHP) 5, the 1,2-DHP 6 or the 1,2,3,4-tetrahydropyrimidines (THPM) 7 as main products. 5-7 were dehydrogenated to the corresponding heteroaromatics 8-10 by cerium(IV). The lactames 11 and 12 were isolated by appropiate reduction of the nitro group from 8 and 9 by neighbour group participation of an ester function. The synthesis of 12 represents for the second time the evidence of an 2-aminofurane compound. 11 and 12 were converted with phosphorous oxychloride to form the annulated chloronaphthyridines 13 and 14 which were cyclized with sodium azide to yield the tetrazoles 15 and 16. The half wave potentials E1/2 of the DHP and THPM 5-7 were determined by anodic oxidation with the rotating platinum electrode using difference pulse voltammetry (DPV). These are comparable with those of the 2-nitrophenyl analogues.

DIRECT FORMYLATION OF NITROARENES VIA VICARIOUS NUCLEOPHILIC SUBSTITUTION OF HYDROGEN

A new method of synthesis of nitroaromatic aldehydes via vicarious nucleophilic substitution of hydrogen with dichloromethyl group and its hydrolysis is described.