41059-79-4 Usage
Description
Timosaponin A-III is a bioactive steroidal saponin compound derived from the Anemarrhena asphodeloides plant. It possesses various pharmacological properties, including anti-inflammatory, anti-cancer, and anti-platelet aggregation effects. Its unique structure and bioactivity make it a promising candidate for pharmaceutical and therapeutic applications.
Uses
Used in Anticancer Applications:
Timosaponin A-III is used as an anticancer agent for its ability to suppress certain human tumor processes. It has shown potential in the development of treatments for various types of cancer, including leukemia and hepatocellular carcinoma. It works by inducing mitochondrial-dependent apoptosis in cancer cells and reversing multi-drug resistance in human chronic myelogenous leukemia K562/ADM cells through the downregulation of MDR1 and MRP1 expression by inhibiting the PI3K/Akt signaling pathway.
Used in Pharmaceutical Industry:
Timosaponin A-III is used as a potent inhibitor of U46619, a compound that induces rat platelet aggregation. It exhibits superior selectivity for the TP receptor compared to other G protein-coupled receptors and acts as a PKC activator. This makes it a valuable compound for the development of drugs targeting platelet aggregation and related conditions, such as thrombosis and cardiovascular diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 41059-79-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,1,0,5 and 9 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 41059-79:
(7*4)+(6*1)+(5*0)+(4*5)+(3*9)+(2*7)+(1*9)=104
104 % 10 = 4
So 41059-79-4 is a valid CAS Registry Number.
InChI:InChI=1/C39H64O13/c1-18-7-12-39(47-17-18)19(2)28-25(52-39)14-24-22-6-5-20-13-21(8-10-37(20,3)23(22)9-11-38(24,28)4)48-36-34(32(45)30(43)27(16-41)50-36)51-35-33(46)31(44)29(42)26(15-40)49-35/h18-36,40-46H,5-17H2,1-4H3/t18?,19-,20+,21-,22+,23-,24-,25-,26+,27+,28-,29+,30-,31-,32-,33+,34+,35-,36+,37-,38-,39+/m0/s1
41059-79-4Relevant articles and documents
STEROID GLYCOSIDES OF THE SEEDS OF Solanum melongena. STRUCTURES OF MELONGOSIDES A, B, E, F, AND H
Kintya, P. K.,Shvets, S. A.
, p. 575 - 578 (2007/10/02)
Three chromatographically individual fractions, each containing tigogenin glycosides and diosgenin glycosides have been isolated by chromatography on a silica gel column from a methanolic extract of eggplant seeds.To separate the mixture of two difficultly separable glycosides into individual components, each fraction was acetylated and epoxidated, and the derivatives obtained were separated chromatographically.The tigogenin glycoside peracetates isolated were saponified, and the diosgenin epoxide glycoside acetates were de-epoxidated and saponified, to give the individual glycosides, melongosides A, B, E, F, and H.The complete chemical structure of each melongoside has been shown with the aid of acid hydrolysis, methylation, and periodate oxidation followed by a study of the products obtained.
