41192-84-1

Basic information

• Product Name: 4-HYDROXY-8-METHOXY-2-(TRIFLUOROMETHYL)QUINOLINE
• Synonyms: 4-HYDROXY-8-METHOXY-2-(TRIFLUOROMETHYL)QUINOLINE;8-METHOXY-2-(TRIFLUOROMETHYL)-4-QUINOLINOL;BUTTPARK 146\04-12;8-METHOXY-2-(TRIFLUOROMETHYL)QUINOLIN-4-OL;8-Methoxy-2-(trifluoromethyl)quinolin-4-ol, 4-Hydroxy-8-methoxy-2-(trifluoromethyl)-1-azanaphthalene;4-Hydroxy-8-methoxy-2-(trifluoromethyl)quinoline97%
• CAS NO: 41192-84-1
• Molecular Formula: C₁₁H₈F₃NO₂
• Molecular Weight: 243.18
• Mol File: 41192-84-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 276.1 °C at 760 mmHg
• Flash Point: 120.8 °C
• Appearance: /
• Density: 1.372 g/cm³
• Vapor Pressure: 0.00491mmHg at 25°C
• Refractive Index: 1.509
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-HYDROXY-8-METHOXY-2-(TRIFLUOROMETHYL)QUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXY-8-METHOXY-2-(TRIFLUOROMETHYL)QUINOLINE(41192-84-1)
• EPA Substance Registry System: 4-HYDROXY-8-METHOXY-2-(TRIFLUOROMETHYL)QUINOLINE(41192-84-1)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 41192-84-1(Hazardous Substances Data)

Usage

General Description

4-Hydroxy-8-Methoxy-2-(Trifluoromethyl)Quinoline is a chemical compound that belongs to the quinoline family. Quinolines are a group of organic compounds, known for their aromatic and heterocyclic properties, that are widely used in medicinal chemistry for their various biological properties. Specifically, the 4-Hydroxy-8-Methoxy-2-(Trifluoromethyl)Quinoline has hydroxy, methoxy, and trifluoromethyl functional groups attached to the quinoline ring. The presence of these groups likely impacts the compound's properties such as reactivity, solubility, and potential bioactivity. However, specific information about this particular compound, such as its uses, toxicity, or involvement in any biological processes, is not readily available, indicating that it may not be widely studied or used.

InChI:InChI=1/C11H8F3NO2/c1-17-8-4-2-3-6-7(16)5-9(11(12,13)14)15-10(6)8/h2-5H,1H3,(H,15,16)

Upstream product

• 371-26-6 ethyl 4,4,4-trifluorobutanoate 
• 90-04-0 2-methoxy-phenylamine 
• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 

Downstream Products

• 41192-89-6 4-chloro-8-methoxy-2-trifluoromethyl-quinoline 
• 199872-29-2 8-Methoxy-2-(trifluoromethyl)quinoline-5-carboxylic acid 
• 41958-07-0 3-benzyl-7-methoxy-5-trifluoromethyl-3,4-dihydro-2H-[1,3]oxazino[5,6-c]quinoline 

Relevant articles and documents

Design, Synthesis, and Antifungal Evaluation of Novel Quinoline Derivatives Inspired from Natural Quinine Alkaloids

Inspired by quinine and its analogues, we designed, synthesized, and evaluated two series of quinoline small molecular compounds (a and 2a) and six series of quinoline derivatives (3a-f) for their antifungal activities. The results showed that compounds 3e and 3f series exhibited significant fungicidal activities. Significantly, compounds 3f-4 (EC50 = 0.41 μg/mL) and 3f-28 (EC50 = 0.55 μg/mL) displayed the superior in vitro fungicidal activity and the potent in vivo curative effect against Sclerotinia sclerotiorum. Preliminary mechanism studies showed that compounds 3f-4 and 3f-28 could cause changes in the cell membrane permeability, accumulation of reactive oxygen species, loss of mitochondrial membrane potential, and effective inhibition of germination and formation of S. sclerotiorum sclerotia. These results indicate that compounds 3f-4 and 3f-28 are novel potential fungicidal candidates against S. sclerotiorum derived from natural products.

PYRIDAZINONE DERIVATIVE AND PDE INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT

It is to provide a novel pyridazinone derivative represented by the following general formula (1), which is useful as a pharmaceutical and has a phosphodiesterase inhibitory action: wherein R1 represents H or C1-6 alkyl, each of R2 and R3 represents H, X, C1-6 alkoxy, Z represents O or S, and A represents AA or BB, wherein AA represents: and BB represents: wherein R4 represents H or C1-6 alkyl, and each of R5 and R6 represents C1-6 alkyl.

THIAZOLIDINE DERIVATIVE AND MEDICINAL USE THEREOF

A thiazolidine derivative represented by the formula (I) wherein each symbol is as defined in the specification, and a pharmaceutically acceptable salt thereof exhibit a potent DPP-IV inhibitory activity, and can be provided as an agent for the prophylaxis or treatment of diabetes, an agent for the prophylaxis or treatment of obesity and the like.