4122-79-6

Basic information

• Product Name: Piperazine, 1-methyl-4-(oxiranylmethyl)- (9CI)
• Synonyms: Piperazine, 1-methyl-4-(oxiranylmethyl)- (9CI);1-METHYL-4-(OXIRAN-2-YLMETHYL)PIPERAZINE
• CAS NO: 4122-79-6
• Molecular Formula: C₈H₁₆N₂O
• Molecular Weight: 156.22544
• Product Categories: PIPERIDINE
• Mol File: 4122-79-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Piperazine, 1-methyl-4-(oxiranylmethyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 1-methyl-4-(oxiranylmethyl)- (9CI)(4122-79-6)
• EPA Substance Registry System: Piperazine, 1-methyl-4-(oxiranylmethyl)- (9CI)(4122-79-6)

Safety Data

• Hazardous Substances Data: 4122-79-6(Hazardous Substances Data)

Upstream product

• 109-01-3 1-methyl-piperazine 
• 106-89-8 epichlorohydrin 

Downstream Products

• 1092361-82-4 C₂₆H₃₄F₃N₃O₂S₂ 
• 412308-64-6 3-Amino-5-<4-methyl-piperazinomethyl>-oxazolid-2-on 
• 101932-30-3 5-<4-Methyl-piperazinomethyl>-3-<5-nitro-furfurylidenamino>-oxazolid-2-on 

Relevant articles and documents

Innovative Disulfide Esters of Dithiocarbamic Acid as Women-Controlled Contraceptive Microbicides: A Bioisosterism Approach

In an ongoing effort to discover an effective, topical, dual-function, non-surfactant contraceptive vaginal microbicide, a novel series of 2,2′-disulfanediylbis(3-(substituted-1-yl)propane-2,1-diyl) disubstituted-1-carbodithioates were designed by using a bioisosterism approach. Thirty-three compounds were synthesized, and interestingly, most demonstrated multiple activities: they were found to be spermicidal at a minimal effective concentration of 1-0.001 %, trichomonacidal against drug-susceptible and resistant Trichomonas strains at minimal inhibitory concentration (MIC) ranges of 10.81-377.64 and 10.81-754.14 μM, respectively, and fungicidal at MIC 7.93-86.50 μM. These compounds were also found to be non-cytotoxic to human cervical (HeLa) epithelial cells and vaginal microflora (Lactobacilli) in vitro. The most promising compound, 2,2′-disulfanediylbis(3-(pyrrolidin-1-yl)propane-2,1-diyl)dipyrrolidine-1-carbodithioate (5), exhibited spermicidal activity 15-fold higher than that of the marketed spermicide Nonoxynol-9 (N-9) and also demonstrated microbicidal potency. To identify common structural features required for spermicidal activity, a 3D-QSAR analysis was carried out, as well as in vivo efficacy studies and fluorescent labeling studies to determine the biological targets of compound 5. Change it out: A series of disulfide esters of dithiocarbamic acid were synthesized to block free sulfhydryl groups present in sperm and Trichomonas for a safe dual-action spermicide. A majority of the compounds demonstrated multiple activities with good safety profiles, with the most promising compound exhibiting spermicidal activity 15-fold higher than that of the marketed spermicide Nonoxynol-9.

PREPARATION AND PHARMACOLOGICAL PROPERTIES OF SOME

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