412293-88-0

Basic information

• Product Name: N-Boc-4-Dimethylaminopiperidine
• Synonyms: N-BOC-4-DIMETHYLAMINOPIPERIDINE;1-Piperidinecarboxylic acid, 4-(dimethylamino)-, 1,1-dimethylethyl ester;tert-Butyl 4-(diMethylaMino)piperidine-1-carboxylate;4-Dimethylamino-piperidine-1-carboxylic acid tert-butyl ester
• CAS NO: 412293-88-0
• Molecular Formula: C₁₂H₂₄N₂O₂
• Molecular Weight: 228.33
• Mol File: 412293-88-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 295.431 °C at 760 mmHg
• Flash Point: 132.472 °C
• Appearance: /
• Density: 1.012 g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.49
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-Boc-4-Dimethylaminopiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-4-Dimethylaminopiperidine(412293-88-0)
• EPA Substance Registry System: N-Boc-4-Dimethylaminopiperidine(412293-88-0)

Safety Data

• Hazardous Substances Data: 412293-88-0(Hazardous Substances Data)

Usage

General Description

N-Boc-4-Dimethylaminopiperidine is a chemical compound with the molecular formula C15H28N2O2. It is a tertiary amine and a piperidine derivative. N-Boc-4-Dimethylaminopiperidine is commonly used as a building block in organic synthesis, particularly in the pharmaceutical industry for the production of various drugs and pharmaceutical products. It is also utilized as a reagent in chemical reactions for the modification and functionalization of organic molecules. N-Boc-4-Dimethylaminopiperidine is a white to off-white crystalline powder and is typically stored and handled under controlled conditions due to its reactivity and potential hazards.

InChI:InChI=1/C12H24N2O2/c1-12(2,3)16-11(15)14-8-6-10(7-9-14)13(4)5/h10H,6-9H2,1-5H3

Upstream product

• 506-59-2 N,N-dimethylammonium chloride 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 124-40-3 dimethyl amine 

Downstream Products

• 4876-59-9 4-(dimethylamino)piperidine dihydrochloride 

Relevant articles and documents

Gedatolisib intermediates for preparation of (by machine translation)

The invention belongs to the organic synthesis and bulk drug intermediate preparation field, in particular to a method for preparing Gedatolisib, key intermediate and a key intermediate in the preparation method. The nitrobenzene nitrile and dicyanodiamine polyisobutylene triazine cyclization, morpholine link guan huan, hydrogenation of nitro reduction to obtain 4 - (4, 6 - II morpholino - 1, 3, 5 - triazine - 2 - yl) aniline; 4 - oxo-piperidine - 1 - carboxylic acid tert-butyl and dimethylamine salt by addition, de-Boc protecting group, amide, hydrogenation of nitro reduction to get new compounds (4 - aminophenyl) (4 - (dimethyl amino) piperidine - 1 - yl) methyl ketone; adopts the one-pot synthesis, (4, 6 - II morpholino - 1, 3, 5 - triazine - 2 - yl) aniline and chloromethane acid ester after the reaction, then adding (4 - aminophenyl) (4 - (dimethyl amino) piperidine - 1 - yl) methanone, to finally obtain the Gedatolisib. This preparation method has the advantages of easy availability of raw materials, process is simple, easy to operate, high yield and low cost and the like. (by machine translation)