412302-13-7

Basic information

• Product Name: N,N-dimethyl-2,2-diphenyl-4-[4-(2-hydroxyphenyl)piperidin-1-yl]butanamide
• Synonyms: N,N-dimethyl-2,2-diphenyl-4-[4-(2-hydroxyphenyl)piperidin-1-yl]butanamide
• CAS NO: 412302-13-7
• Molecular Weight: 442.601
• Mol File: 412302-13-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N,N-dimethyl-2,2-diphenyl-4-[4-(2-hydroxyphenyl)piperidin-1-yl]butanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dimethyl-2,2-diphenyl-4-[4-(2-hydroxyphenyl)piperidin-1-yl]butanamide(412302-13-7)
• EPA Substance Registry System: N,N-dimethyl-2,2-diphenyl-4-[4-(2-hydroxyphenyl)piperidin-1-yl]butanamide(412302-13-7)

Safety Data

• Hazardous Substances Data: 412302-13-7(Hazardous Substances Data)

Upstream product

• 58333-75-8 4-(2-methoxyphenyl)piperidine 
• 37743-18-3 N-(dihydro-3,3-diphenyl-2(3H)-furanylidene)-N-methylmethanaminium bromide 
• 161609-76-3 4-(2-hydroxyphenyl)-piperidine 

Downstream Products

• 412302-21-7 ethyl [2-[1-[4-(dimethylamino)-3,3-diphenyl-4-oxobutyl]piperidin-4-yl]phenoxy]acetate 

Relevant articles and documents

New μ-opioid receptor agonists with phenoxyacetic acid moiety

New μ-opioid receptor (MOR) agonists containing 4-hydroxypiperidine, piperidine and piperazine moieties were synthesized and evaluated to find a peripheral opioid analgesic. Among the synthesized compounds, [2-[1-[3-(N,N-dimethylcarbamoyl)-3,3-diphenylpropyl]-4-hydroxypiperidin-4-yl] phenoxy]acetic acid (8: SS620) having phenoxyacetic acid and 4-hydroxypiperidine moieties showed the highest agonist potency on the MOR in an isolated guinea-pig ileum preparation, and it also had selectivity to the human MOR expressed in Chinese hamster ovary (CHO)-K1 cells compared with the same types of δ- and κ-opioid receptors (DOR and KOR). In addition, compound 8 showed a 10 times more potent MOR agonist activity than loperamide. Furthermore, compound 8 showed a peripheral analgesic activity in vivo screening on rat.