41252-95-3

Basic information

• Product Name: 1-CHLORO-4-IODO-2-NITROBENZENE
• Synonyms: 1-CHLORO-4-IODONITROBENZENE;1-CHLORO-4-IODO-2-NITROBENZENE;2-Chloro-5-iodonitrobenzene;4-Chloro-3-nitrophenyl iodide;1-chloro-4-iodine-2-nitrobenzene
• CAS NO: 41252-95-3
• Molecular Formula: C₆H₃ClINO₂
• Molecular Weight: 283.45
• Mol File: 41252-95-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 74.5 °C
• Boiling Point: 311.3±22.0 °C(Predicted)
• Appearance: /
• Density: 2.094
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 1-CHLORO-4-IODO-2-NITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CHLORO-4-IODO-2-NITROBENZENE(41252-95-3)
• EPA Substance Registry System: 1-CHLORO-4-IODO-2-NITROBENZENE(41252-95-3)

Safety Data

• Hazardous Substances Data: 41252-95-3(Hazardous Substances Data)

Usage

General Description

1-Chloro-4-iodo-2-nitrobenzene is a chemical compound with the molecular formula C6H4ClINO2. It is a halogenated nitrobenzene with a chloro, iodo, and nitro group attached to a benzene ring. 1-CHLORO-4-IODO-2-NITROBENZENE is commonly used in the production of pharmaceuticals, dyes, and other organic chemicals. It is also used as an intermediate in the synthesis of various organic compounds. 1-Chloro-4-iodo-2-nitrobenzene is also used as a reagent in organic reactions, particularly in the synthesis of complex molecules. Due to its unique structure, this compound has various applications in organic chemistry and chemical synthesis.

Upstream product

• 88-73-3 2-Chloronitrobenzene 
• 4771-47-5 3-chloro-2-nitro-benzoic acid 
• 96-99-1 4-chloro-3-nitrobenzoate 
• 637-87-6 1-Chloro-4-iodobenzene 
• 38818-50-7 4-chloro-3-nitro-benzoyl chloride 
• 610-41-3 3,4-dinitroaniline 
• 635-22-3 4-Chloro-3-nitroaniline 

Downstream Products

• 919103-45-0 6-iodo-1,3-dihydro-indol-2-one 
• 1573120-04-3 dimethyl 2-(4-iodo-2-nitrophen-1-yl)malonate 
• 1338507-93-9 diethyl 2-(4-iodo-2-nitrophen-1-yl)malonate 
• 110723-51-8 N-tert-butyl-4-chloro-3-nitrobenzamide 
• 1360597-27-8 N-methyl-N-[4-(phenylsulfonyl)-1,1'-biphenyl-3-yl]amine 
• 1360597-28-9 N-methyl-2-(phenylsulfonyl)-5-(pyridin-3-yl)aniline 
• 1360598-10-2 N-(2-(phenylsulfonyl)-5-(pyridin-3-yl)phenyl)formamide 
• 1360598-09-9 2-(phenylsulfonyl)-5-(pyridin-3-yl)phenylamine 
• 1360598-08-8 3-(3-nitro-4-(phenylsulfonyl)phenyl)pyridine 
• 1360598-07-7 N-(4-(phenylsulfonyl)biphenyl-3-yl)formamide 
• 1360598-06-6 4-(phenylsulfonyl)biphenyl-3-amine 
• 1360598-05-5 3-nitro-4-phenylsulfonylbiphenyl 
• 1360598-04-4 4-iodo-2-nitro-1-(phenylsulfonyl)benzene 
• 1331759-20-6 5,6-diphenyl-3-(4-chloro-3-nitrobenzyl)imidazo[2,1-b]thiazole 

Relevant articles and documents

Pd-Catalyzed Decarboxylative Ortho-Halogenation of Aryl Carboxylic Acids with Sodium Halide NaX Using Carboxyl as a Traceless Directing Group

A highly regioselective Pd-catalyzed carboxyl directed decarboxylative ortho-C-H halogenation of cheap o-nitrobenzoic acids with NaX (X = I, Br) under aerobic conditions has been established. The utility of the method has been demonstrated by the gram-scale reaction and derivatization of the product. Experimental results have confirmed Pd and Bi played critical roles in the transformation and indicated the transformation might proceed via 2-halo-6-nitrobenzoic acid derivative intermediate.

Method for synthesizing m-iodonitrobenzene compound

Provided is a method for synthesizing m-iodonitrobenzene; in the presence of oxygen gas, a palladium catalyst, a copper additive, a bismuth reagent and potassium phosphate, an o-nitrobenzoic acid compound and metal iodide are subjected to a substitution reaction in an organic solvent to form a corresponding m-iodonitrobenzene compound, wherein a metal in the metal iodide is an alkali metal or an alkaline earth metal. The method has obvious advantages of cheap and easily obtained reaction raw materials (including o-nitrobenzoic acid and MI), small amount of the metal catalyst, minimum environmental pollution with oxygen gas as an oxidant, good tolerance on various functional groups on an aromatic ring and the like. The method can be widely applied in the fields of synthesis of drugs, materials, natural products and the like in industrial and academic circles.

PROCESS FOR PREPARING 6-IODO-2-OXINDOLE

Disclosed is a method for the synthesis of 6-iodo-2-oxindole useful as intermediate in the manufacture of pharmaceutically active ingredients. Also disclosed is a novel intermediate used in the synthesis of this compound.