41252-96-4

Basic information

• Product Name: 3-CHLORO-4-IODONITROBENZENE
• Synonyms: BUTTPARK 29\07-57;2-CHLORO-1-IODO-4-NITROBENZENE;3-CHLORO-4-IODONITROBENZENE;2-Chloro-1-iodonitrobenzene;1-Iodo-2-chloro-4-nitrobenzene;2-Chloro-4-nitro-1-iodobenzene;1-CHLORO-2-IODO-5-NITROBENZENE
• CAS NO: 41252-96-4
• Molecular Formula: C₆H₃ClINO₂
• Molecular Weight: 283.45
• EINECS: 255-278-8
• Mol File: 41252-96-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 94 °C
• Boiling Point: 312.9 °C at 760 mmHg
• Flash Point: 143 °C
• Appearance: /
• Density: 2.094 g/cm³
• Vapor Pressure: 0.000946mmHg at 25°C
• Refractive Index: 1.671
• Storage Temp.: 2-8°C(protect from light)
• Water Solubility: Slightly soluble in water.
• Sensitive: Light Sensitive
• BRN: 2502411
• CAS DataBase Reference: 3-CHLORO-4-IODONITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-4-IODONITROBENZENE(41252-96-4)
• EPA Substance Registry System: 3-CHLORO-4-IODONITROBENZENE(41252-96-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT, LIGHT SENSITIVE, IRRIT
• Hazardous Substances Data: 41252-96-4(Hazardous Substances Data)

Usage

Description

3-CHLORO-4-IODONITROBENZENE is an organic compound that serves as an important intermediate in the synthesis of various chemicals and pharmaceuticals. It is characterized by its unique molecular structure, which includes a chlorine atom at the 3rd position, an iodine atom at the 4th position, and a nitro group attached to the benzene ring.

Uses

Used in Chemical Synthesis:
3-CHLORO-4-IODONITROBENZENE is used as a key intermediate in the production of 3-chloro-4-trifluoromethylaniline. This synthesis involves a two-step reaction process, where trifluoromethylcopper reacts with 3-CHLORO-4-IODONITROBENZENE, leading to the formation of the desired product.
In the Chemical Industry:
3-CHLORO-4-IODONITROBENZENE is utilized as a starting material for the synthesis of various organic compounds, including pharmaceuticals, dyes, and other specialty chemicals. Its unique structure allows for further functionalization and modification, making it a versatile building block in the chemical industry.
In the Pharmaceutical Industry:
As an intermediate, 3-CHLORO-4-IODONITROBENZENE plays a crucial role in the development of new drugs and pharmaceuticals. Its derivatives can be used to target specific biological pathways or receptors, potentially leading to the discovery of novel therapeutic agents for various diseases and medical conditions.

InChI:InChI=1/C6H3ClINO2/c7-5-3-4(9(10)11)1-2-6(5)8/h1-3H

Upstream product

• 99-54-7 3,4-dichloronitrobenzene 
• 24616-42-0 2-chloro-4-nitro-benzenediazonium; chloride 
• 401631-87-6 C₁₀H₁₃ClN₄O₂ 
• 615-41-8 2-iodochlorobenzene 
• 7697-37-2 nitric acid 
• 121-73-3 3-Nitrochlorobenzene 
• 97-02-9 2,4-Dinitroanilin 
• 121-87-9 2-Chloro-4-nitroaniline 

Downstream Products

• 151504-80-2 3-Chloro-4-trifluoromethyl-nitrobenzene 
• 179687-02-6 (2-chloro-4-nitrophenyl)(pyridin-2-yl)methanol 
• 193902-80-6 tert-butyl 4-(2-chloro-4-nitro-phenyl)piperazine-1-carboxylate 
• 55435-71-7 4-(2-chloro-4-nitrophenyl)morpholine 
• 135050-44-1 3-chloro-4-iodoaniline 

Relevant articles and documents

IMIDAZOLE BIARYL COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS

The present disclosure is directed to compounds of formula (Ie) and pharmaceutically acceptable salts thereof, wherein A, B, R1, R2, m, n, X1, X2, X3 and X4 are as defined herein, which are active as inhibitors of S-Nitrosoglutathione reductase (GSNOR). These compounds prevent, inhibit, or suppress the action of GSNOR and are therefore useful in the treatment of GSNOR mediated diseases, disorders, syndromes or conditions such as, e.g., pulmonary hypertension, acute respiratory distress syndrome (ARDS), asthma, bronchospasm, cough, pneumonia, pulmonary fibrosis, interstitial lung diseases, cystic fibrosis and chronic obstructive pulmonary disease (COPD).

2-Methoxy-4-nitrobenzenediazonium salt as a practical diazonium-transfer agent for primary arylamines via tautomerism of 1,3-diaryltriazenes: Deaminative iodination and arylation of arylamines without direct diazotization

1,3-Diaryltriazenes, prepared from a 2-methoxy-4-nitrobenzenediazonium salt and primary arylamines, exist as "azo-transfer" tautomers in which the 2-methoxy-4-nitrophenyl group is present on the saturated nitrogen atom and forms a hydrogen bond between the 2-methoxy group and the N-H moiety. The synthetic utility of the diazonium salt as a practical diazonium-transfer agent for primary arylamines via tautomerism of the 1,3-diaryltriazenes has been demonstrated by the deaminative iodination and arylation of the arylamines without direct diazotization. The starting 2-methoxy-4-nitrophenylamine can be easily recovered after the reactions.

Sporidesmins. XIX. The diazotization and coupling in acid of p-nitro- and 2,4-dinitro-aniline to veratrole or guaiacol: 1H N.M.R. of the products in deuterochloroform and deuteroacetone

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