41259-65-8

Basic information

• Product Name: 6-CHLORO-N4-PHENYL-4,5-PYRIMIDINEDIAMINE
• Synonyms: 6-CHLORO-N4-PHENYL-4,5-PYRIMIDINEDIAMINE;6-Chloro-N4-phenylpyriMidine-4,5-diaMine
• CAS NO: 41259-65-8
• Molecular Formula: C₁₀H₉ClN₄
• Molecular Weight: 220.66
• Mol File: 41259-65-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 372.865°C at 760 mmHg
• Flash Point: 179.303°C
• Appearance: /
• Density: 1.413g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.709
• PKA: 2.37±0.10(Predicted)
• CAS DataBase Reference: 6-CHLORO-N4-PHENYL-4,5-PYRIMIDINEDIAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-N4-PHENYL-4,5-PYRIMIDINEDIAMINE(41259-65-8)
• EPA Substance Registry System: 6-CHLORO-N4-PHENYL-4,5-PYRIMIDINEDIAMINE(41259-65-8)

Safety Data

• Hazardous Substances Data: 41259-65-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H9ClN4/c11-9-8(12)10(14-6-13-9)15-7-4-2-1-3-5-7/h1-6H,12H2,(H,13,14,15)

Upstream product

• 5413-85-4 5-amino-4,6-dichloropyridimine 
• 62-53-3 aniline 

Downstream Products

• 5470-24-6 6-Chloro-9-phenyl-9H-purine 
• 84905-75-9 N-phenyl-5H-pyrrolo[3,2-d]pyrimidin-4-amine 
• 70538-58-8 6-chloro-8-methyl-9-phenyl-9H-purine 
• 17466-00-1 7-chloro-3-phenyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine 
• 1237764-74-7 6-chloro-9-phenyl-7,9-dihydro-8H-purin-8-one 
• 1427273-11-7 C₁₉H₁₇N₅O₂ 
• 417943-05-6 6-amino-9-phenyl-7H-purin-8(9H)-one 
• 1307786-15-7 3-(8,9-diphenyl-9H-purin-6-ylamino)propanal 
• 1307786-13-5 3-(8,9-diphenyl-9H-purin-6-ylamino)propan-1-ol 
• 1307786-11-3 8,9-diphenyl-1H-purin-6(9H)-one 
• 851072-03-2 6-chloro-8,9-diphenyl-9H-purine 
• 1307783-19-2 N-(3-(4-(2,3-dimethylphenyl)piperazin-1-yl)propyl)-8,9-diphenyl-9H-purine-6-amine 
• 1307783-18-1 N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl)-8,9-diphenyl-9H-purine-6-amine 
• 1307786-09-9 N-(4-chloro-6-(phenylamino)pyrimidin-5-yl)benzamide 

Relevant articles and documents

A One-Pot Synthesis of Highly Functionalized Purines

Highly substituted purines were synthesized in good to high yields through a one-pot straightforward metal-free scalable method, using the Traube synthesis adapted to Vilsmeier-type reagents. From 5-amino-4-chloropyrimidines, new 9-aryl-substituted chloropurines and intermediates for peptide nucleic acid synthesis were prepared. Variant procedures allowing a rapid synthesis of ribonucleosides and 7-benzylpurine from 5-amidino-6-aminopyrimidines are also reported to illustrate the high potential of this versatile toolbox. This route appears to be particularly interesting in the field of nucleic acids for a direct and rapid access to various new 8-alkylpurine nucleosides.

An efficient synthesis of 4,6-substituted pyrrolo[3,2-d]pyrimidines by silver-catalyzed cyclization of acetylene amine

A silver catalyzed cyclization of acetylene amine was developed to synthesize 4,6-substituted pyrrolo[3,2-d]pyrimidine, a bioactive isosteric scaffold of purine. Starting from simple commercially available acetylenes and pyrimidines, the method was found

GLUCOSE TRANSPORT INHIBITORS

The present invention relates to chemical compounds of general formula (I): in which RA, RB, RC, RD, m, and n are as given in the description and in the claims, and which effectively and selectively inhibit glucose transporter 1 (GLUT1), to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.