41292-65-3

Basic information

• Product Name: 1H-Benzimidazol-5-ol
• Synonyms: 1H-Benzimidazol-5-ol;1H-Benzimidazol-5-ol(9CI);5-hydroxybenzimidazole;6-Hydroxy-1H-benzimidazole;5-Hydroxybenzo[d]iMidazole;5-Hydroxy-3H-benzimidazole, 1H-Benzimidazol-6-ol, 3H-Benzimidazol-5-ol, 5-Hydroxy-1H-benzimidazole, 1H-Benzimidazol-5-ol;1H-benzo[d]iMidazol-6-ol;1H-BenziMidazol-6-ol
• CAS NO: 41292-65-3
• Molecular Formula: C₇H₆N₂O
• Molecular Weight: 134.14
• Product Categories: BENZIMIDAZOLE;pharmacetical
• Mol File: 41292-65-3.mol
• Article Data: 11

Chemical Properties

• Melting Point: 220-222℃
• Boiling Point: 469.135 °C at 760 mmHg
• Flash Point: 237.524 °C
• Appearance: /
• Density: 1.434 g/cm³
• Vapor Pressure: 2.01E-09mmHg at 25°C
• Refractive Index: 1.76
• Storage Temp.: 2-8°C
• PKA: 9.20±0.40(Predicted)
• CAS DataBase Reference: 1H-Benzimidazol-5-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazol-5-ol(41292-65-3)
• EPA Substance Registry System: 1H-Benzimidazol-5-ol(41292-65-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 41292-65-3(Hazardous Substances Data)

Usage

General Description

1H-Benzimidazol-5-ol, also known as 5-hydroxybenzimidazole, is a chemical compound with the molecular formula C7H6N2O. It belongs to the class of benzimidazole derivatives and is a heterocyclic compound with a bicyclic structure. 1H-Benzimidazol-5-ol has a hydroxy group attached to the 5th carbon atom of the benzimidazole ring. It is commonly used in the synthesis of pharmaceuticals and organic compounds, and it exhibits biological activities such as anti-inflammatory and anti-ulcer properties. The compound has also been studied for its potential applications in material science, such as in the development of corrosion inhibitors and organic light-emitting diodes. 1H-Benzimidazol-5-ol is an important intermediate in the production of various functionalized benzimidazole derivatives and has shown promising potential for future research and industrial applications.

InChI:InChI=1/C7H6N2O/c10-5-1-2-6-7(3-5)9-4-8-6/h1-4,10H,(H,8,9)

Upstream product

• 4887-80-3 5-methoxy-1H-benzimidazole 
• 50591-21-4 5-ethoxybenzimidazole 
• 64-18-6 formic acid 
• 610-81-1 4-hydroxy-2-nitroaniline 
• 106658-14-4 4-methoxy-1,2-phenylenediamine hydrochloride 
• 122-51-0 orthoformic acid triethyl ester 
• 25635-88-5 5-amino-1-(β-D-ribofuranosyl)imidazole 5'-phosphate 
• 102-51-2 4-methoxy-1,2-phenylenediamine 
• 16133-49-6 5-methoxy-2-nitroaniline 

Downstream Products

• 670220-88-9 1-(2-(5-((3-methyloxetan-3-yl)methoxy)-1H-benzo[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine 
• 816463-40-8 tert-butyl N-[1-(2-{5-[(3-methyloxetan-3-yl)methoxy]-1H-1,3-benzodiazol-1-yl}quinolin-8-yl)piperidin-4-yl]carbamate 
• 287395-90-8 4-(3H-benzoimidazol-5-yloxy)-piperidine-1-carboxylic acid tert-butyl ester 
• 124841-30-1 4-Chloro-1H-benzoimidazol-5-ol 
• 64265-10-7 4-nitro-1(3)H-benzimidazol-5-ol 
• 128728-05-2 4-(5-Hydroxy-1H-benzoimidazol-4-ylazo)-benzenesulfonic acid 
• 128728-03-0 4-Phenylazo-1H-benzoimidazol-5-ol 
• 128728-04-1 4-(4-Nitro-phenylazo)-1H-benzoimidazol-5-ol 
• 57050-67-6 4-(dimethylaminomethyl)-5-hydroxybenzimidazole 

Relevant articles and documents

Microwave use of amidine compounds in the aqueous phase benzoate synthesis of benzimidazole compounds method

The invention discloses a microwave the use of amidine compounds in the aqueous phase benzoate synthesis of benzimidazole compounds, in the aqueous phase under microwave conditions adding benzoic amidine compound under alkaline condition [...] into benzimidazole reaction, invention an environment-friendly, the operation is simple, cheap and safe, efficient process for preparing benzimidazole method. Compared with the prior art, this method not only can be applied to a large number of functional groups, the productive rate is high, few by-products, and the operation is simple, safe, low cost, environmental protection; .

A novel series of benzimidazole NR2B-selective NMDA receptor antagonists

A series of novel benzimidazoles are discussed as NR2B-selective N-methyl-d-aspartate (NMDA) receptor antagonists. High throughput screening (HTS) efforts identified a number of potent and selective NR2B antagonists such as 1. Exploration of the substituents around the core of this template identified a number of compounds with high potency for NR2B (pIC50 >7) and good selectivity against the NR2A subunit (pIC50 2+ and radioligand binding studies. These agents offer potential for the development of therapeutics for a range of nervous system disorders including chronic pain, neurodegeneration, migraine and major depression.

Highly efficient and scalable process for demethylation of 6-(2,4-dimethoxybenzoyl)chromen-2-one and other aryl methyl ethers

Demethylation of 6-(2,4-dimethoxybenzoyl)chromen-2-one and some other aryl methyl ethers was achieved with pyridinium bromide as demethylating agent and sulfolane as solvent. Compared with other demethylation methods, this combination offers advantages of clean conversion, excellent yields, easy operation and workup, and manageable reaction temperatures. This process could be particularly useful for large-scale production because it avoids use of corrosive or moisture-sensitive reagents. Copyright