4132-55-2Relevant articles and documents
INHIBITORS OF MTOR-DEPTOR INTERACTIONS AND METHODS OF USE THEREOF
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Page/Page column 40, (2018/05/24)
Provided herein are substituted hydrazone compounds useful as inhibitors of DEPTOR. The invention further provides pharmaceutical compositions of the compounds of the invention. The invention also provides medical uses of substituted hydrazone compounds.
Keten. Part 17. Addition Reactions of Ketens with N-Phenyl Nitrones
Hafiz, Mushtag,Taylor, Giles A.
, p. 1700 - 1705 (2007/10/02)
The N-phenyl nitrones (1a), (4b), and (15) react with ketens in two totally different ways.Triphenylnitrone (4b) forms oxidolones (6) whereas (1a) and (15) form oxazolidinones (2) and (17).The differences appear to be caused by steric interactions in (1a) and (15) which distort the nitrone function and prevent the N-phenyl group adopting the conformation necessary for the oxindole-forming pathway.