41339-67-7

Basic information

• Product Name: 8-Desethyl Etodolac
• Synonyms: 8-Desethyl Etodolac;1-Ethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid;Etodolac impurity A -L
• CAS NO: 41339-67-7
• Molecular Formula: C15H16NO3
• Molecular Weight: 258.29244
• Product Categories: Amines, Heterocycles, Indole Derivatives, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 41339-67-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 137-140℃
• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 8-Desethyl Etodolac(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Desethyl Etodolac(41339-67-7)
• EPA Substance Registry System: 8-Desethyl Etodolac(41339-67-7)

Safety Data

• Hazardous Substances Data: 41339-67-7(Hazardous Substances Data)

Usage

Description

8-Desethyl Etodolac, also known as Etodolac Impurity A, is a chemical compound that is identified as an impurity in Etodolac (E933100). Etodolac is a nonsteroidal anti-inflammatory drug (NSAID) used for the treatment of pain and inflammation. The presence of 8-Desethyl Etodolac as an impurity in Etodolac has been a subject of interest due to its potential mutagenicity, which was examined in reverse mutation tests on bacteria.

Uses

Used in Pharmaceutical Industry:
8-Desethyl Etodolac is used as an impurity in the drug Etodolac (E933100) for the purpose of evaluating its mutagenicity in reverse mutation tests on bacteria. This is important for ensuring the safety and efficacy of the final drug product, as understanding the potential mutagenic effects of impurities can help in assessing the overall risk profile of the medication.
Additionally, the study of 8-Desethyl Etodolac as an impurity can provide valuable insights into the manufacturing process of Etodolac, allowing for improvements in quality control and the development of more stringent guidelines for the production of NSAIDs. This can ultimately contribute to the overall safety and effectiveness of these medications for patients.

Upstream product

• 111962-14-2 (1-ethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol-1-yl)-acetic acid ethyl ester 
• 526-55-6 2-(3-indole)-ethanol 
• 4949-44-4 ethyl propanoylacetate 

Relevant articles and documents

SUBSTITUTED INDOLE DERIVATIVES

Provided herein are indole derivatives, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.

1,3,4,9-Tetrahydropyrano[3,4-b]indole-1-acetamides and derivatives

Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole or 1,3,4,9-tetrahydrothiopyrano[3,4-b]indole nucleus bearing a substituent in position 1, said substituent incorporating an acid, ester or amide function therein, are discl