41343-22-0

Basic information

• Product Name: (2E)-1-(2-naphthyl)-3-(2,4,5-trimethoxyphenyl)-2-propen-1-one
• Synonyms: (2E)-1-(2-naphthyl)-3-(2,4,5-trimethoxyphenyl)-2-propen-1-one
• CAS NO: 41343-22-0
• Molecular Weight: 348.398
• Mol File: 41343-22-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2E)-1-(2-naphthyl)-3-(2,4,5-trimethoxyphenyl)-2-propen-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-1-(2-naphthyl)-3-(2,4,5-trimethoxyphenyl)-2-propen-1-one(41343-22-0)
• EPA Substance Registry System: (2E)-1-(2-naphthyl)-3-(2,4,5-trimethoxyphenyl)-2-propen-1-one(41343-22-0)

Safety Data

• Hazardous Substances Data: 41343-22-0(Hazardous Substances Data)

Upstream product

• 4460-86-0 asaraldehyde 
• 93-08-3 methyl 2-naphthyl ketone 

Relevant articles and documents

Naphthylchalcones induce apoptosis and caspase activation in a leukemia cell line: The relationship between mitochondrial damage, oxidative stress, and cell death

In this study, we investigated the effects of 24 chalcone derivatives from 2-naphthylacetophenone toward a lymphoblastic leukemia cell line (L1210). Three compounds, called R7, R13, and R15, presented concentration- and time-dependent cytotoxicity and induced cellular death by apoptosis via mitochondrial injury and oxidative stress. The effects of these compounds appear to occur through different mechanisms because R13 and R7 induced a greater disturbance of mitochondrial potential, and all compounds induced disturbances of cellular ATP content and increased caspase-3 activity before cellular death. These compounds also interfered with antioxidant enzymes activities and GSH content through different mechanisms.