41444-62-6 Usage
Description
Codeine phosphate is a white or almost white, crystalline powder or small, colorless crystals that is commonly used as an antitussive and analgesic (narcotic). It is a pharmaceutical compound derived from the opium poppy plant and is known for its pain-relieving and cough-suppressing properties.
Uses
Used in Pharmaceutical Industry:
Codeine phosphate is used as an antitussive for suppressing coughs. It works by acting on the cough center in the brain to reduce the urge to cough, providing relief for individuals suffering from persistent or dry coughs.
Codeine phosphate is also used as an analgesic for managing mild to moderate pain. It is an opioid narcotic that works by binding to opioid receptors in the brain and spinal cord, reducing the perception of pain and providing relief for those experiencing discomfort.
Used in Cough Syrup Industry:
In the cough syrup industry, codeine phosphate is used as an active ingredient in various cough syrup formulations. It is commonly found in products such as Cough Syrup (Parke-Davis) and Colrex Compound (Solvay Pharmaceuticals), where it helps to alleviate coughing and provide temporary relief from cough-related symptoms.
Used in Branded Medicines:
Codeine phosphate is also used in the formulation of branded medicines, such as Ambenyl, which is a combination of codeine phosphate and other ingredients designed to provide relief from cough and cold symptoms. This brand name medication is specifically formulated to target the symptoms of cough and cold, making it a popular choice for consumers seeking relief from these conditions.
Originator
Actacode Linctus,Sigma
Clinical Use
Codeine is used extensively to treat moderate to mild pain. Codeine is a weak μ agonist, but
approximately 10% of an oral dose (30–60 mg) is metabolized to morphine, which contributes significantly to its analgesic effect. The plasma
half-life of codeine after oral dose is 3.5 hours. The dose of codeine needed to produce analgesia
after parenteral dose causes releases of histamine sufficient to produce hypotension, pruritus, and
other allergic responses. Thus, administration of codeine by parenteral route is not recommended.
Veterinary Drugs and Treatments
In small animal medicine, codeine is used principally as an oral
analgesic
when salicylates are not effective and parenteral opiates
are not warranted. It may also be useful as an antitussive
or an
antidiarrheal.
Drug interactions
Potentially hazardous interactions with other drugs
Antibacterials: metabolism increased by rifampicin.
Antidepressants: possible CNS excitation or
depression with MAOIs - avoid concomitant use,
and for 2 weeks after stopping MAOI; possible
CNS excitation or depression with moclobemide;
increased sedative effects with tricyclics.
Antihistamines: increased sedative effects with
sedating antihistamines.
Antipsychotics: enhanced hypotensive and sedative
effects.
Dopaminergics: avoid with selegiline.
Nalmefene: avoid concomitant use.
Sodium oxybate: enhanced effect of sodium oxybate
- avoid.
Metabolism
Codeine is metabolised by O- and N-demethylation in
the liver to morphine, norcodeine, and other metabolites
including normorphine and hydrocodone. Metabolism to
morphine is mediated by the cytochrome P450 isoenzyme
CYP2D6, which shows genetic polymorphism.Codeine and its metabolites are excreted almost entirely
by the kidney, mainly as conjugates with glucuronic acid.
Check Digit Verification of cas no
The CAS Registry Mumber 41444-62-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,1,4,4 and 4 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 41444-62:
(7*4)+(6*1)+(5*4)+(4*4)+(3*4)+(2*6)+(1*2)=96
96 % 10 = 6
So 41444-62-6 is a valid CAS Registry Number.
InChI:InChI=1/C18H21NO3.H3O4P.H2O/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19;1-5(2,3)4;/h3-6,11-13,17,20H,7-9H2,1-2H3;(H3,1,2,3,4);1H2/t11-,12+,13-,17-,18-;;/m0../s1
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