41478-45-9

Basic information

• Product Name: diethyl 2-(2-(benzyloxy)ethyl)Malonate
• Synonyms: diethyl 2-(2-(benzyloxy)ethyl)Malonate;Propanedioic acid, [2-(phenylmethoxy)ethyl]-, diethyl ester
• CAS NO: 41478-45-9
• Molecular Formula: C₁₆H₂₂O₅
• Molecular Weight: 294.34288
• Mol File: 41478-45-9.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: diethyl 2-(2-(benzyloxy)ethyl)Malonate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 2-(2-(benzyloxy)ethyl)Malonate(41478-45-9)
• EPA Substance Registry System: diethyl 2-(2-(benzyloxy)ethyl)Malonate(41478-45-9)

Safety Data

• Hazardous Substances Data: 41478-45-9(Hazardous Substances Data)

Usage

General Description

Diethyl 2-(2-(benzyloxy)ethyl)malonate is an organic compound that belongs to the class of malonic esters. It is commonly used in organic synthesis as a building block for the preparation of various pharmaceutical and agrochemical products. diethyl 2-(2-(benzyloxy)ethyl)Malonate is used in the preparation of important intermediates, such as amino alcohols, that are widely employed in the pharmaceutical industry. Its unique structure and reactivity make it a valuable tool for the synthesis of complex molecules and can be used in a wide range of reactions, including esterification, alkylation, and condensation. Additionally, diethyl 2-(2-(benzyloxy)ethyl)malonate is often utilized as a key starting material for the production of dyes, pigments, and other fine chemicals.

Upstream product

• 54555-84-9 benzyl iodoethyl ether 
• 105-53-3 diethyl malonate 
• 96-49-1 [1,3]-dioxolan-2-one 
• 1208672-17-6 benzyl-2-bromoethyl ether 
• 4981-83-3 2-(Benzyloxy)ethyl p-toluenesulfonate 
• 58841-52-4 2-(benzyloxy)ethyl methanesulfonate 
• 622-08-2 2-Benzyloxyethanol 
• 1462-37-9 bromoethyl-2-benzyl ether 
• 17229-17-3 benzyl 2-chloroethyl ether 
• 996-82-7 sodium diethylmalonate 

Downstream Products

• 119951-31-4 diethyl 2-benzyloxyethyl(2-tetrahydropyran-2-yloxyethyl)malonate 
• 118602-97-4 ethyl 4-[(phenylmethyl)oxy]butanoate 
• 77661-80-4 2-(2-(benzyloxy)ethyl)propane-1,3-diol 
• 149876-89-1 2-(2-benzyloxyethyl)malonamide 
• 251922-46-0 2-(oxetan-3-yl)ethan-1-ol 
• 569678-81-5 3-(2-(benzyloxy)ethyl)oxetane 
• 569678-80-4 toluene-4-sulfonic acid 4-benzyloxy-2-hydroxymethyl-butyl ester 
• 50873-93-3 [(4-chlorobutoxy)methyl]benzene 
• 4541-14-4 4-benzyloxy-butan-1-ol 
• 856061-94-4 bis-(4-benzyloxy-butyl)-sulfide 
• 172644-62-1 diethyl 2-(2-(benzyloxy)ethyl)-2-fluoromalonate 
• 874196-41-5 N,N'-bis-(2-aminoethyl)-2-(2-benzyloxy-ethyl)malonamide 
• 874196-42-6 N,N'-bis(2-amino-ethyl)-2-(2-benzyloxyethyl)-1,3-diaminopropane 
• 874196-43-7 N,N'-bis(2-tert-butoxycarbonylamino-ethyl)-2-(2-benzyloxyethyl)-1,3-di(tert-butoxycarbonylamino)propane 

Relevant articles and documents

Guanidinium-Functionalized Flexible Azaproline Transporter for Efficient Intracellular Delivery of Proapoptotic Peptide and PDL1 Antisense Morpholino Oligo in Human Carcinoma Cells in Vitro

Cell-penetrating peptides (CPPs) are structurally diverse sophisticated tools endowed with high arginine content, amphipathicity, and well-adopted suitable secondary structures. Despite its capability of breaching the lipid barriers, CPP has major limitations such as in vivo metabolic instability, poor bioavailability, and reduced endosomal escape tendency, which are yet to be improved. In this context, we first have introduced a new class of cellular transporter having a guanidinium-functionalized δ-azaproline (δ-azp)-containing peptide where the δ-azp structurally resembles the proline amino acid having an additional N at the δ-position. This non-natural peptidic backbone was found to impart proteolytic stability, as reported earlier by our group. Herein, we report the synthesis of a flexible azaproline-tetraguanidinium transporter named FAT along with a revised scalable methodology for δ-azp compared to our previously reported procedure. FAT shows a random-coil-like structure as determined by CD spectroscopy, and is hence structurally different from the polyproline PPII helix. Direct translocation is predicted to be the possible mode of the cellular entrance of FAT into CHO cells when the Bodipy fluorophore is covalently attached as the cargo. Simultaneously, two other macromolecular therapeutics, e.g., proapoptotic domain peptide (PAD, a 14-mer peptide) and programmed death ligand 1 (PDL1) morpholino (a 25-mer antisense oligo), were successfully conjugated with FAT and delivered into human carcinoma cells, and their efficacy was analyzed by MTT assay and western blot technique, respectively. Having obtained promising results in internalizing different types of cargos, FAT could be envisaged as a potential drug delivery agent as an alternative to natural CPPs for future application.

Compounds, liquid crystal composition, liquid crystal display element and liquid crystal display

The invention relates to compounds, a liquid crystal composition, a liquid crystal display element and a liquid crystal display. The compounds are represented by a formula I shown in the description.The liquid crystal composition provided by the invention

METHOD OF CONTROLLING LACTATE PRODUCTION WITH PIPERDINE-DIONE DERIVATIVES

The invention provides novel compounds having the general formula: and tautomers and pharmaceutically acceptable salts thereof, wherein A1, A2, A3, A4, R1, R4, R5, R6, R7 and R8 are as defined herein, compositions including the compounds and methods of using the compounds.