414909-98-1

Basic information

• Product Name: Benzyl 3,4-dihydro-2-(4-fluoro-2-methylphenyl)-4-oxopyridine-1(2H)-carboxylate, 1-[(Benzyloxy)carbonyl]-2-(4-fluoro-2-methylphenyl)-4-oxo-1,2,3,4-tetrahydropyridine
• Synonyms: 2,3-Dihydro-2-(4-fluoro-2-methylphenyl)pyridin-4(1H)-one, N-CBZ protected;Benzyl 3,4-dihydro-2-(4-fluoro-2-methylphenyl)-4-oxopyridine-1(2H)-carboxylate, 1-[(Benzyloxy)carbonyl]-2-(4-fluoro-2-methylphenyl)-4-oxo-1,2,3,4-tetrahydropyridine;1(2H)-Pyridinecarboxylic acid, 2-(4-fluoro-2-Methylphenyl)-3,4-dihydro-4-oxo-, phenylMethyl ester;Benzyl 2-(4-fluoro-2-methylphenyl)-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate
• CAS NO: 414909-98-1
• Molecular Formula: C₂₀H₁₈FNO₃
• Molecular Weight: 339.3602232
• Mol File: 414909-98-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 492.981°C at 760 mmHg
• Flash Point: 251.946°C
• Appearance: /
• Density: 1.256g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.589
• PKA: -5.12±0.40(Predicted)
• CAS DataBase Reference: Benzyl 3,4-dihydro-2-(4-fluoro-2-methylphenyl)-4-oxopyridine-1(2H)-carboxylate, 1-[(Benzyloxy)carbonyl]-2-(4-fluoro-2-methylphenyl)-4-oxo-1,2,3,4-tetrahydropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: Benzyl 3,4-dihydro-2-(4-fluoro-2-methylphenyl)-4-oxopyridine-1(2H)-carboxylate, 1-[(Benzyloxy)carbonyl]-2-(4-fluoro-2-methylphenyl)-4-oxo-1,2,3,4-tetrahydropyridine(414909-98-1)
• EPA Substance Registry System: Benzyl 3,4-dihydro-2-(4-fluoro-2-methylphenyl)-4-oxopyridine-1(2H)-carboxylate, 1-[(Benzyloxy)carbonyl]-2-(4-fluoro-2-methylphenyl)-4-oxo-1,2,3,4-tetrahydropyridine(414909-98-1)

Safety Data

• Hazardous Substances Data: 414909-98-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C20H18FNO3/c1-14-11-16(21)7-8-18(14)19-12-17(23)9-10-22(19)20(24)25-13-15-5-3-2-4-6-15/h2-11,19H,12-13H2,1H3

Upstream product

• 620-08-6 4-methoxypyridine 
• 452-63-1 2-Bromo-5-fluorotoluene 
• 501-53-1 benzyl chloroformate 
• 7439-95-4 magnesium 

Downstream Products

• 414910-14-8 (2R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4-oxo-1-piperidinecarboxamide 
• 579475-69-7 2-(4-fluoro-2-methylphenyl)-4-piperidinone camphor-10-sulfonate 
• 758683-83-9 C₂₈H₃₂F₇N₃O 
• 732982-99-9 C₂₈H₃₂F₇N₃O 
• 692257-60-6 C₂₇H₃₀F₇N₃O 
• 740081-53-2 C₂₇H₃₀F₇N₃O 
• 1265855-31-9 C₂₇H₃₀F₇N₃O 
• 1265855-27-3 C₂₇H₃₀F₇N₃O 
• 1265854-91-8 C₂₆H₂₈F₇N₃O 
• 578710-96-0 C₂₆H₃₀F₇N₃O 
• 578710-94-8 C₂₆H₃₀F₇N₃O 
• 578711-00-9 C₂₅H₂₈F₇N₃O 
• 578710-98-2 C₂₅H₂₈F₇N₃O 
• 414910-03-5 (2R)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4-oxo-1-piperidinecarboxamide 

Relevant articles and documents

Discovery and biological characterization of (2 R,4 S)-1′-Acetyl- N -{(1 R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)- N -methyl-4,4′-bipiperidine-1-carboxamide as a new potent and selective neurokinin 1 (NK1) recepto

A large body of compelling preclinical evidence supports the clinical use of neurokinin (NK) receptor antagonists in a plethora of CNS and non-CNS therapeutic areas. The significant investment made in this area over the past 2 decades culminated with the

PIPERIDINE COMPOUND AND METHOD FOR PRODUCING SAME

The present invention relates to a novel piperidine compound represented by the formula [I]: wherein Ring A represents an optionally substituted benzene ring, Ring B represents an optionally substituted benzene ring, R1 represents an optionally

NK1 ANTAGONIST

The invention is to a compound exhibiting neurokinin inhibitory properties, a pharmaceutical composition comprising same and a method of treatment for neurokinin-meditated conditions.Formula (I)