41536-72-5Relevant articles and documents
Thermal Risk Analysis Based on Reaction Mechanism: Application to the 2,6-Diaminopyrazine-1-oxide Synthesis Process
Li, Yuehua,Wang, Yang,Liao, Longyu,Guo, Zichao,Chen, Liping,Wu, Wenqian
, p. 849 - 857 (2021)
Thermal risk analysis is essential for the development of chemical reactions. This work should be carried out on the basis of a thorough comprehension of the reaction mechanism. In this article, the synthesis process for 2,6-diaminopyrazine-1-oxide (DAPO), an important intermediate in the synthesis of the famous explosive 2,6-diamino-3,5-dinitropyrazine-1-oxide (LLM-105), was employed to show the importance of understanding the reaction mechanism for thermal risk analysis. First, we investigated the reaction mechanism of DAPO synthesis. The reaction mechanism was divided into two stages on the basis of the amount of triethylamine dosed: the first half of triethylamine dosing and the second half of triethylamine dosing until the end of the reaction. Then the thermal properties of DAPO synthesis and the thermal stability of the materials involved were experimentally studied using a reaction calorimeter (RC1) and a differential scanning calorimeter (DSC), respectively. The results show that the temperature corresponding to the maximum reaction rate reached in a time of 24 h under adiabatic conditions (TD24) is higher than the maximum temperature of the synthesis reaction (MTSR) for both of these stages, indicating that once cooling failure occurs, immediately stopping addition of triethylamine could prevent the occurrence of secondary decomposition.
Method for synthesizing 2,6-diamido-pyrazine-1-oxide by using one-pot method
-
Paragraph 0033-0035; 0041-0049, (2018/12/05)
The invention discloses a method for synthesizing 2,6-diamido-pyrazine-1-oxide by using a one-pot method and aims to solve the problems of low yields, high impurity contents, intensive conditions, long cycles, heavy waste generation, high cost and inadequacy of industrial production in the prior art. The method for synthesizing 2,6-diamido-pyrazine-1-oxide by using the one-pot method has a synthesis route as shown in the description. The method is high in yield, high in purity, gentle in synthesis condition, short in synthesis cycle, low in waste generation, low in cost and applicable to industrial production.
New synthesis of 2,6-diamino-3,5-dinitropyrazine-1-oxide from 2,6-diaminopyrazine-1-oxide
-
Page/Page column 3, (2009/12/23)
A method for the synthesis of 2,6-Diamino-3,5-dinitropyrazine-1-oxide including nitration of 2,6-diaminopyrazine-1-oxide. The step of nitration may use nitrating agents 20% Oleum/100% HNO3, 100% HNO3 and conc. H2504/100% HNO3 or nitronium tetrfluoraoborate. The synthesis of 2,6-diaminopyrazine-1-oxide may involve both the oxidation of 2,6-diaminopyrazine, the amination of a precursor 2,6-disubstitutedpyrazine-1-oxide or direct formation of the 2,6-diaminopyrazine-l-oxide from the precursor, 2-amino-6-hydroxamino-pyrazine-1-oxide.
