415679-09-3

Basic information

• Product Name: 2-cyclohexyl-1-(3-fluorophenyl)-2-oxoethyl propionate
• CAS NO: 415679-09-3
• Molecular Weight: 292.35
• Mol File: 415679-09-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-cyclohexyl-1-(3-fluorophenyl)-2-oxoethyl propionate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-cyclohexyl-1-(3-fluorophenyl)-2-oxoethyl propionate(415679-09-3)
• EPA Substance Registry System: 2-cyclohexyl-1-(3-fluorophenyl)-2-oxoethyl propionate(415679-09-3)

Safety Data

• Hazardous Substances Data: 415679-09-3(Hazardous Substances Data)

Upstream product

• 327-62-8 potassium propionate 
• 2719-27-9 cyclohexanylcarbonyl chloride 

Downstream Products

• 415679-10-6 4-cyclohexyl-5-(3-fluorophenyl)-2-ethyloxazole 

Relevant articles and documents

4-(4-cycloalkyl/aryl-oxazol-5-yl)benzenesulfonamides as selective cyclooxygenase-2 inhibitors: Enhancement of the selectivity by introduction of a fluorine atom and identification of a potent, highly selective, and orally active COX-2 inhibitor JTE-522

A series of 4-(4-cycloalkyl/aryl-oxazol-5-yl)benzenesulfonamide derivatives were synthesized and evaluated for their abilities to inhibit cyclooxygenase-2 (COX-2) and cyclooxygenase-1 (COX-1) enzymes. In this series, substituent effects at the ortho position to the sulfonamide group on the phenyl ring were examined. Most substituents reduced or lost both COX-2 and COX-1 activities. In contrast, introduction of a fluorine atom preserved COX-2 potency and notably increased COX1/COX-2 selectivity. This work led to the identification of a potent, highly selective, and orally active COX-2 inhibitor JTE-522 [9d, 4-(4-cyclohexyl-2-methyloxazol-5-yl)-2-fluorobenzenesulfonamide], which is currently in phase II clinical trials for the treatment of rheumatoid arthritis, osteoarthritis, and acute pain.