41621-49-2 Usage
Description
Ciclopirox ethanolamine, also known as the ethanolamine salt of ciclopirox, is a broad-spectrum antifungal agent with some antibacterial activity. It is chemically unrelated to other antifungal agents and works by inhibiting the transmembrane transport of substrates and ions, leading to intracellular depletion. Ciclopirox ethanolamine also possesses anti-inflammatory properties and is commonly used as a topical treatment for fungal skin and nail infections.
Uses
Used in Pharmaceutical Industry:
Ciclopirox ethanolamine is used as a broad-spectrum antifungal agent for the treatment of various fungal infections, particularly skin and nail infections. It is effective against dermatophytes, yeast, and Pityrosporum orbiculare, as well as demonstrating activity against Trichomonas vaginalis, some mycoplasma, and some gram-positive and gram-negative bacteria.
Used in Antifungal Applications:
Ciclopirox ethanolamine is used as an antifungal agent for its effectiveness against a wide range of fungi, including dermatophytes, yeast, and Pityrosporum orbiculare. Its unique mode of action and chemical properties make it a valuable addition to the arsenal of antifungal treatments.
Used in Antibacterial Applications:
Ciclopirox ethanolamine is used as an antibacterial agent, exhibiting activity against many Gram-positive and Gram-negative bacteria. This dual functionality as both an antifungal and antibacterial agent makes it a versatile compound in the treatment of various infections.
Used in Anti-inflammatory Applications:
Ciclopirox ethanolamine is used as an anti-inflammatory agent due to its ability to reduce inflammation associated with fungal and bacterial infections. This property enhances its effectiveness in treating skin and nail infections, providing relief from discomfort and promoting faster healing.
Brand Name:
Ciclopirox ethanolamine is marketed under the brand name Loprox, manufactured by Hoechst-Roussel.
Originator
Batrafen ,Cassella-Riedel, W. Germany ,1980
Indications
Ciclopirox olamine (Loprox, Penlac) is a synthetic, broad-spectrum hydroxypyridone
antifungal agent. It is chemically unrelated to the imidazoles or
any other antifungal agent currently available in the United States. It appears
to act through intracellular depletion of substrates and/or ions principally
by inhibition of transmembrane transport of these substances. It is active
against dermatophytes, yeast, and Pityrosporum orbiculare. It also demonstrates
activity against Trichomonas vaginalis, some mycoplasma, and some
gram-positive and gram-negative bacteria.
Manufacturing Process
Ciclopirox may be produced as follows: 2 g of 4-methyl-6-cyclohexyl-2-pyrone
were heated with 1 g of hydroxylamine hydrochloride and 5 g of 2-aminopyridine to 80 C for 8 hours.
The reaction mixture was then dissolved in methylene chloride, the amine was
removed by shaking with dilute hydrochloric acid, the reaction product was
extracted from the organic phase by means of dilute sodium hydroxide
solution and the alkaline solution was acidified with acetic acid to a pH value
of 6. The 1-hydroxy-4-cnethyl-6-cyclohexyl-2-pyridone precipitated in
crystalline form. It was filtered off with suction, washed with water and dried.
The yield was 1.05 g (49% of theory); melting point 143 C.
Reaction of ciclopirox with ethanolamine gives the desired prod
Therapeutic Function
Antifungal
Biological Activity
ciclopirox ethanolamine, working as an iron chelator, suppresses a substantial number of clinically relevant dermatophytes, yeasts, and molds, including the frequently azole-resistant candida species candida glabrata, candida krusei, and candida guilliermondii. moreover, ciclopirox has been proved to inhibit a wide range of bacteria in humans, including many gram-positive and gram-negative species pathogenic bacteria. [1]
Clinical Use
6-Cyclohexyl-1-hydroxyl-4-methyl-2(1H)-pyridinoneethanolamine salt (Loprox) is a broad-spectrum antifungalagent intended only for topical use. It is active against dermatophytesas well as pathogenic yeasts (C. albicans) thatare causative agents for superficial fungal infections.Ciclopirox is considered an agent of choice in the treatmentof cutaneous candidiasis, tinea corporis, tinea cruris,tinea pedis, and tinea versicolor. It is a second-line agent forthe treatment of onychomycosis (ringworm of the nails).Loprox is formulated as a cream and a lotion, each containing1% of the water-soluble ethanolamine salt. Ciclopirox isbelieved to act on cell membranes of susceptible fungi atlow concentrations to block the transport of amino acids intothe cells. At higher concentrations, membrane integrity islost, and cellular constituents leak out.
Clinical Use
Ciclopirox olamine (Loprox) is a pyridone derivative
available for the treatment of cutaneous dermatophyte
infections, cutaneous C. albicans infections, and tinea
versicolor caused by Malassezia furfur. It interferes with
fungal growth by inhibiting macromolecule synthesis.
Safety Profile
Poison by intravenous andintraperitoneal routes. Moderately toxic by ingestion andsubcutaneous routes. Experimental reproductive effects.When heated to decomposition it emits toxic fumes ofNOx.
in vitro
ciclopirox inhibited dermatophytes and yeasts pathogenic with mics of 0.98-3.9 μg/ml. studies from c. albicans cells demonstrated that after being rapidly absorbed, ciclopirox largely accumulated intracellular with a concentration of 200 times greater than those in the medium. high concentration of ciclopirox resulted in the loss of folin-positive substances and potassium ions, by this way this agent could lead to cellular leakage without breaking the cell wall. similarly, by decreasing the uptake of precursors of the macromolecules or by decreasing the uptake of essential ions such as potassium ions and phosphate, ciclopirox blocked the synthesis of protein, rna, and dna in growing fungal cells. the chelation of metal ions and the suppression of iron-dependent enzymes were crucial for ciclopirox to exert antifungal effects. ciclopirox alone intensively suppressed the growth of aspergillus fumigatus b5233 conidia. ciclopirox also exhibited synergistic antifungal effect when being combined used with ketoconazole. [1]
in vivo
the effect of ciclopirox on endogenous hif-1 target gene-vegf was investigated using different animal organ models including mouse skin wound model, rat kidney model and chicken chorioallantoic membrane model. according to the results, cpx functionally activated hif-1, induced vegf expression and accelerated angiogenesis. [2]
IC 50
ciclopirox ethanolamine, a broad-spectrum antifungal agent, inhibits dermatophytes and yeasts pathogenic with a minimal inhibitory concentration (mic) of 0.98-3.9 μg/ml.
references
[1]niewerth m, kunze d, seibold m, schaller m, korting hc and hube b. ciclopirox olamine treatment affects the expression pattern of candida albicans genes encoding virulence factors, iron metabolism proteins, and drug resistance factors. antimicrob agents chem. 2003 jun; 47(6): 180517. [2]linden t, katschinski dr, eckhardt k, scheid a, pagel h and wenger rh. the antimycotic ciclopirox olamine induces hif-1 stability, vegf expression, and angiogenesis. faseb. 2003 feb; 17: 761–3.[3]subissi a, monti d, togni g and mailland f. recent nonclinical and clinical data relevant to its use as a topical antimycotic agent. drugs. 2010 nov; 70(16): 2133-52.
Check Digit Verification of cas no
The CAS Registry Mumber 41621-49-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,1,6,2 and 1 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 41621-49:
(7*4)+(6*1)+(5*6)+(4*2)+(3*1)+(2*4)+(1*9)=92
92 % 10 = 2
So 41621-49-2 is a valid CAS Registry Number.
InChI:InChI=1/C12H17NO2.C2H7NO/c1-9-7-11(13(15)12(14)8-9)10-5-3-2-4-6-10;3-1-2-4/h7-8,10,15H,2-6H2,1H3;4H,1-3H2
41621-49-2Relevant articles and documents
Synthesis method of ciclopirox olamine
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, (2017/12/29)
The invention discloses a synthesis method of ciclopirox olamine. The synthesis method includes following steps: (1), preparing dimethyl methacrylate; (2), preparing cyclohexane formyl chloride; (3), preparing 5-oxo-3-methyl-5-cyclohexyl-3-methyl pentenoate; (4), preparing 1-hydroxy-4-methyl-6-cyclohexyl-2(1H)-pyridone; (5), preparing 1-hydroxy-4-methyl-6-cyclohexyl-2(1H)-pyridone-2-amino-ethylate ciclopirox olamine. The synthesis method has the advantages of high yield, high product quality, low running cost, automatic running of equipment, high stability and easiness in meeting industrial needs.