4166-00-1

Basic information

• Product Name: 5-Thioxopyrrolidin-2-one
• Synonyms: 5-Thioxopyrrolidin-2-one;USAF WI-1
• CAS NO: 4166-00-1
• Molecular Formula: C₄H₅NOS
• Molecular Weight: 115.16
• Mol File: 4166-00-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 113°C
• Boiling Point: 110°C
• Appearance: /solid
• Density: 1.225 (estimate)
• Refractive Index: 1.5130 (estimate)
• CAS DataBase Reference: 5-Thioxopyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Thioxopyrrolidin-2-one(4166-00-1)
• EPA Substance Registry System: 5-Thioxopyrrolidin-2-one(4166-00-1)

Safety Data

• Hazardous Substances Data: 4166-00-1(Hazardous Substances Data)

Usage

General Description

5-Thioxopyrrolidin-2-one is a chemical compound with the molecular formula C4H5NOS. It is a heterocyclic compound containing a five-membered ring with a sulfur atom and a carbonyl group. 5-Thioxopyrrolidin-2-one is commonly used in organic synthesis and pharmaceutical research. It has potential applications in the development of new drugs and as a building block for the synthesis of various biologically active compounds. 5-Thioxopyrrolidin-2-one has also been studied for its antimicrobial and antioxidant properties, making it a promising candidate for further research in the fields of medicine and pharmaceuticals.

InChI:InChI=1/C4H5NOS/c6-3-1-2-4(7)5-3/h1-2H2,(H,5,6,7)

Upstream product

• 147767-13-3 1-Phenethyl-5-thioxo-pyrrolidin-2-one 
• 123-56-8 Succinimide 

Relevant articles and documents

Influence of Lewis acid charge and proximity in MoMo?M linear chain compounds with M = Na+, Ca2+, Sr2+, and Y3+

The syntheses, X-ray structural characterizations, and electrochemical properties of four new paddlewheel [MMo2(SNO5)4Cl](n-1)+ (Mn+ = Na+, Ca2+, Sr2+, Y3+; HSNO5 = monothiosuccinimide) compounds are described here. By changing the Mn+ cation charge and size, we demonstrate a method for easily tuning the Lewis acidity of the MoMo quadruple bond and the [Mo2]4+/5+ redox potential. As the charge of the Mn+ cation is increased, the distal Mo atom becomes more Lewis acidic, leading to a shorter Mo2-Cl bond distance, and the [Mo2]4+/5+ redox couple becomes less accessible. As the Mn+ Mo2 distance is increased, the distal Mo atom becomes less Lewis acidic, leading to a longer Mo2-Cl bond distance.

ARYLOXY-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES

A glucokinase activator is provided; and a treatment and/or a preventive for diabetes, or a treatment and/or a preventive for diabetes such as retinopathy, nephropathy, neurosis, ischemic cardiopathy, arteriosclerosis, and further a treatment and/or a preventive for obesity are provided. The invention relates to a compound of a formula (I): [wherein R1 and R2 represent a hydrogen, etc.; R3 represents a hydrogen atom, a halogen atom, etc.; R4 each independently represents a hydrogen atom, a lower alkyl group, etc.; Q represents a carbon atom, a nitrogen atom or a sulfur atom (the sulfur atom may be mono- or di-substituted with an oxo group); R5 and R6 each represent a hydrogen atom, a lower alkyl group, etc.; X1, X2, X3 and X4 each independently represent a carbon atom or a nitrogen atom; Z represents an oxygen atom, a sulfur atom or a nitrogen atom; Ar represents an aryl or heteroaryl group optionally mono to tri-substituted with a group selected from the substituent group β; ring A represents a 5- or 6-membered nitrogen-containing heteroaromatic group; m indicates an integer of from 1 to 6; n indicates an integer of from 0 to 3; p indicates an integer of from 0 to 2 (provided that at least two of X1 to X4 are carbon atoms); q indicates 0 or 1] or its pharmaceutically-acceptable salt, which has an effect of glucokinase activation and is useful as a treatment for diabetes.

Synthesis and Characterization of Monothiosuccinimides

The synthesis and characterization are described of a series of monothiosuccinimides.These imides are potentially valuable synthetic intermediates, particularly for the preparation of a bile pigments.Also described are the synthesis and unusual chemical and spectral behavior of a monothiomaleimide derivative, whose X-ray crystallographic structure was determined.