416839-38-8

Basic information

• Product Name: 1,3,2-Dioxaborinane, 2-[4-(trifluoromethyl)phenyl]-
• CAS NO: 416839-38-8
• Molecular Formula: C10H10BF3O2
• Molecular Weight: 229.994
• Mol File: 416839-38-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1,3,2-Dioxaborinane, 2-[4-(trifluoromethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,2-Dioxaborinane, 2-[4-(trifluoromethyl)phenyl]-(416839-38-8)
• EPA Substance Registry System: 1,3,2-Dioxaborinane, 2-[4-(trifluoromethyl)phenyl]-(416839-38-8)

Safety Data

• Hazardous Substances Data: 416839-38-8(Hazardous Substances Data)

Usage

General Description

1,3,2-Dioxaborinane, 2-[4-(trifluoromethyl)phenyl]- is a chemical compound with the molecular formula C10H10BF3O2. It is a boron-containing compound that is commonly used in organic synthesis as a versatile reagent for various chemical transformations. It is a white solid with a molecular weight of 218.993 g/mol. 1,3,2-Dioxaborinane, 2-[4-(trifluoromethyl)phenyl]- is known for its ability to undergo cross-coupling reactions with a wide range of organic compounds, making it a valuable tool in the field of organic chemistry. Additionally, the presence of the trifluoromethylphenyl group in the molecule makes it useful for the synthesis of pharmaceuticals and agrochemicals.

Upstream product

• 149104-90-5 4-acetylphenylboronic acid 
• 504-63-2 trimethyleneglycol 
• 128796-39-4 4-trifluoromethylphenylboronic acid 

Downstream Products

• 581-80-6 4,4'-bis(trifluoromethyl)biphenyl 
• 57132-19-1 4-(4-(trifluoromethyl)phenyl)butan-2-one 
• 42916-66-5 1-(4-(trifluoromethyl)phenyl)pentan-1-one 
• 1431616-05-5 2-(4-trifluoromethylphenyl)-1-[3-(trifluoromethyl)pyridin-2-yl]piperidine 
• 1370412-44-4 3-methyl-N-{phenyl[4-(trifluoromethyl)phenyl]methyl}-pyridin-2-amine 
• 395-23-3 phenyl(4-(trifluoromethyl)phenyl)methanol 

Relevant articles and documents

P(III)/P(V)-Catalyzed Methylamination of Arylboronic Acids and Esters: Reductive C-N Coupling with Nitromethane as a Methylamine Surrogate

The direct reductive N-arylation of nitromethane by organophosphorus-catalyzed reductive C-N coupling with arylboronic acid derivatives is reported. This method operates by the action of a small ring organophosphorus-based catalyst (1,2,2,3,4,4-hexamethylphosphetane P-oxide) together with a mild terminal reductant hydrosilane to drive the selective installation of the methylamino group to (hetero)aromatic boronic acids and esters. This method also provides for a unified synthetic approach to isotopically labeled N-methylanilines from various stable isotopologues of nitromethane (i.e., CD3NO2, CH315NO2, and 13CH3NO2), revealing this easy-to-handle compound as a versatile precursor for the direct installation of the methylamino group.

Ruthenium(0)-catalyzed sp3 C-H bond arylation of benzylic amines using arylboronates

A Ru-catalyzed direct arylation of benzylic sp3 carbons of acyclic amines with arylboronates is reported. This highly regioselective and efficient transformation can be performed with various combinations of N-(2-pyridyl) substituted benzylamines and arylboronates. Substitution of the pyridine directing group in the 3-position proved to be crucial in order to achieve high arylation yields. Furthermore, the pyridine directing group can be removed in high yields via a two-step protocol.