41743-71-9

Basic information

• Product Name: ruizgenin
• Synonyms: ruizgenin;3β,6β-Chlorogenin
• CAS NO: 41743-71-9
• Molecular Formula: C₂₇H₄₄O₄
• Molecular Weight: 432.6359
• Product Categories: Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 41743-71-9.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 550.5°Cat760mmHg
• Flash Point: 286.7°C
• Appearance: /
• Density: 1.16g/cm³
• Vapor Pressure: 2.07E-14mmHg at 25°C
• Refractive Index: 1.564
• CAS DataBase Reference: ruizgenin(CAS DataBase Reference)
• NIST Chemistry Reference: ruizgenin(41743-71-9)
• EPA Substance Registry System: ruizgenin(41743-71-9)

Safety Data

• Hazardous Substances Data: 41743-71-9(Hazardous Substances Data)

Usage

Description

Ruizgenin is a naturally occurring compound that can be derived from various plant sources. It possesses a unique chemical structure that grants it a range of biological activities, making it a potential candidate for pharmaceutical and industrial applications.

Uses

Used in Pharmaceutical Industry:
Ruizgenin is used as an anti-inflammatory agent for its ability to provide antioxidant benefits and promote cardiovascular health. It is derived from chlorogenic acid and is obtained from garlic, which is known for its various health-promoting properties.
Used in Antioxidant Applications:
Ruizgenin is utilized as an antioxidant in the pharmaceutical and nutraceutical industries due to its ability to neutralize free radicals and protect cells from oxidative stress. This application can be beneficial in the development of supplements and medications aimed at promoting overall health and well-being.
Used in Drug Delivery Systems:
In the field of drug delivery, ruizgenin can be employed as a component in the design of novel drug delivery systems. Its unique chemical properties may allow for improved targeting and release of therapeutic agents, enhancing the efficacy and bioavailability of medications.
Used in Cosmetics Industry:
Ruizgenin may also find applications in the cosmetics industry, where its antioxidant and anti-inflammatory properties can be harnessed to develop products that promote skin health and protect against environmental stressors.

InChI:InChI=1/C27H44O4/c1-15-5-10-27(30-14-15)16(2)24-23(31-27)13-20-18-12-22(29)21-11-17(28)6-8-25(21,3)19(18)7-9-26(20,24)4/h15-24,28-29H,5-14H2,1-4H3/t15-,16+,17+,18-,19+,20+,21-,22-,23+,24+,25-,26+,27?/m1/s1

Upstream product

• 555-31-7 aluminum isopropoxide 
• 67-63-0 isopropyl alcohol 
• 3514-59-8 (25R)-5α-spirostan-3,6-dione 
• 512-04-9 diosgenin 
• 7647-01-0 hydrogenchloride 
• 511-91-1 neochlorogenin acetate 
• 64-17-5 ethanol 
• 562-33-4 (25R)-5α,20αH-Spirostan-3β,6α-diol 
• 111372-85-1 (25R)-6α-hydroxy-5α-spirostan-3-one 
• 511-91-1 chlorogenin 
• 20470-24-0 (25R)-3β-hydroxy-5α-spirostan-6-one 
• 72994-87-7 (25R,5α)-spirostan-3β,6β-diol 3-O-β-D-glucopyranosyl-(1>2)-[β-D-glucopyranosyl-(1>3)]-β-D-glucopyranosyl-(1>4)-β-D-galactopyranoside 

Downstream Products

• 6057-65-4 Di-O-benzoyl-chlorogenin 
• 1672-65-7 (1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^2,9.0^4,8.0^13,18]icosa-16,18-diene-6,2'-oxane] 
• 20470-24-0 (25R)-3β-hydroxy-5α-spirostan-6-one 
• 334491-30-4 (23S,25R)-5α-spirostan-3β,6β,23-triol 

Relevant articles and documents

Steroidal Glycosides from the Flowers of Allium leucanthum

Furostanol and spirostanol glycosides 1 and 2 were isolated from the flowers of Allium leucanthum, a Caucasian endemic species that grows in Georgia. The structures were established on the base of chemical evidence and spectral analyses ( 1 H, 13 C NMR, 1 H- 1 H COSY, 1 H- 13 C COSY, HMBC, and HR-MS) data. Compound 1 (leucofuranoside A) was reported for the first time and was identified as 26-O-β-Dglucopyranosyl-(25R)-5α-furostane-3β,6β-diol-3-O-β-D-glucopyranosyl-(1→2)-O-β-D-xylopyranosyl-(1→3)-O-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside. Compound 2 was identified as (25R)-5α-spirostane-3β,6β-diol-3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside and described for the first time in the genus Allium.

Trans -Hydroboration-oxidation products in ?5-steroids via a hydroboration- retro -hydroboration mechanism

Herein, we report for the first time a trans-hydroboration-oxidation product isolated and characterized under traditional hydroboration-oxidation conditions using cholesterol and diosgenin as substrates. These substrates are excellent starting materials because of the rigidity and different structural environments around the double bond. Further investigations based on experimental evidence, in conjunction with theoretical studies, indicate that the formation of this trans-species occurs via a retro-hydroboration of the major product to generate the corresponding ?6-structure and the subsequent hydroboration by the ?-face. Besides, the corresponding Markovnikov type products have been isolated in synthetically useful yields. The behavior of the reaction under a range of temperatures is also investigated.

TIMOSAPONIN COMPOUNDS

Provided herein are timosaponin compounds of Frmula I, II, IIΙ, I', II' and IIΙ', pharmaceutical compositions comprising the coumpounds, and processes of preparation thereof. Also provided are uses of said timosaponin compounds for preparing medicament for the treatment of diseases associated with beta-amyloid in hosts or subjects in need thereof.