41753-55-3

Basic information

• Product Name: Ophiopogonin
• Synonyms: Ophiopogonin;[(25R)-3β-Hydroxyspirost-5-en-1β-yl]2-O-(6-deoxy-α-L-mannopyranosyl)-3-O-(β-D-xylopyranosyl)-6-deoxy-β-D-galactopyranoside
• CAS NO: 41753-55-3
• Molecular Formula: C44H70O16
• Molecular Weight: 855.021
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 41753-55-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.42 g/cm³
• CAS DataBase Reference: Ophiopogonin(CAS DataBase Reference)
• NIST Chemistry Reference: Ophiopogonin(41753-55-3)
• EPA Substance Registry System: Ophiopogonin(41753-55-3)

Safety Data

• Hazardous Substances Data: 41753-55-3(Hazardous Substances Data)

Usage

General Description

Ophiopogonin is a steroidal saponin derived from the root of Ophiopogon japonicus, a traditional Chinese medicinal herb. It has been found to possess various pharmacological activities, including anti-inflammatory, anti-cancer, and immunomodulatory effects. Ophiopogonin has been shown to inhibit the proliferation and induce apoptosis of cancer cells, making it a potential candidate for cancer treatment. Additionally, it has demonstrated anti-inflammatory properties by suppressing the production of pro-inflammatory cytokines and inhibiting the activity of inflammatory enzymes. Furthermore, ophiopogonin has been found to modulate the immune system by promoting the production of certain immune cells and enhancing their activity. Overall, ophiopogonin shows promise as a potential therapeutic agent for a variety of health conditions.

Upstream product

• 1486510-50-2 25(S)-ruscogenin 1-O-α-L-rhamnopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→3)]-4-O-acetyl-β-D-fucopyranoside 

Downstream Products

• 874485-32-2 25(S)-ruscogenin 

Relevant articles and documents

Three new neuritogenic steroidal saponins from Ophiopogon japonicus (Thunb.) Ker-Gawl

Three new steroidal saponins (1-3) and a known saponin (4) were isolated from Ophiopogon japonicus (Thunb.) Ker-Gawl. Their structures were determined by spectroscopic analyses and chemical derivatization. The isolated compounds (1-4) were potent inducers of neuritogenesis on PC12 cells. Compound 1 showed the highest neuritogenic activity of 46% at 1 μM. The study of structure-activity relationships suggests that aglycone is important for the neuritogenic activity of the compounds. Specific inhibitor experiments and Western blot analysis suggest that 1-induced neuritogenic activity depends on the activation of mitogen-activated protein kinase kinase (MEK)/extracellular signal regulated kinase (ERK) signaling pathway on PC12 cells.