4176-52-7Relevant articles and documents
Directed ortho metalation - Cross coupling connections. Remote lateral metalation - Cyclization of 2-Imino-2'-methyl biaryls to 9- aminophenanthrenes. A synthesis of the alkaloid piperolactam C+
Benesch, Lisbeth,Bury, Paul,Guillaneux, Denis,Houldsworth, Stephen,Wang,Snieckus, Victor
, p. 961 - 964 (1998)
2-Imino-2'-methyl biaryls, conveniently available by Suzuki cross coupling protocol, undergo lithium diethyl amide-mediated metalation - cyclization to give 9-aminophonanthrenes (Table 1). The application of this new general methodology to the first synthesis of the alkaloid piperolactam C (9) is described.