4181-97-9

Basic information

• Product Name: 4-METHOXY-BENZOIC ACID PHENYL ESTER
• Synonyms: 4-METHOXY-BENZOIC ACID PHENYL ESTER;Anisalol;Anisic acid phenyl ester;p-Anisic acid phenyl ester;Phenyl 4-Methoxybenzoate
• CAS NO: 4181-97-9
• Molecular Formula: C₁₄H₁₂O₃
• Molecular Weight: 228.24328
• Mol File: 4181-97-9.mol
• Article Data: 78

Chemical Properties

• Melting Point: 73.7 °C
• Boiling Point: 367.7°C at 760 mmHg
• Flash Point: 153.9°C
• Appearance: /
• Density: 1.159g/cm³
• Vapor Pressure: 1.34E-05mmHg at 25°C
• Refractive Index: 1.569
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), DMSO (Slightly)
• CAS DataBase Reference: 4-METHOXY-BENZOIC ACID PHENYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXY-BENZOIC ACID PHENYL ESTER(4181-97-9)
• EPA Substance Registry System: 4-METHOXY-BENZOIC ACID PHENYL ESTER(4181-97-9)

Safety Data

• Hazardous Substances Data: 4181-97-9(Hazardous Substances Data)

Usage

Description

4-METHOXY-BENZOIC ACID PHENYL ESTER, also known as Phenyl 4-Methoxybenzoate, is an organic compound with the molecular formula C14H12O3. It is a derivative of benzoic acid, featuring a methoxy group at the 4-position and an ester linkage with a phenyl group. 4-METHOXY-BENZOIC ACID PHENYL ESTER is known for its potential applications in various fields due to its unique chemical properties.

Uses

Used in Pharmaceutical Industry:
4-METHOXY-BENZOIC ACID PHENYL ESTER is used as a reagent for the synthesis of pyrazoles via iodine catalyzed denitrative imino-diaza-Nazarov cyclization. This application is significant in the development of new pharmaceutical compounds, as pyrazoles are known to possess diverse biological activities, including anti-inflammatory, antifungal, and anticancer properties.
Used in Enzyme Inhibition:
In the field of biochemistry and molecular biology, 4-METHOXY-BENZOIC ACID PHENYL ESTER is used as a potent inhibitor of 15-lipoxygenase, an enzyme involved in the metabolism of fatty acids and the production of inflammatory mediators. By inhibiting this enzyme, the compound may contribute to the development of treatments for various inflammatory diseases and conditions.

InChI:InChI=1/C14H12O3/c1-16-12-9-7-11(8-10-12)14(15)17-13-5-3-2-4-6-13/h2-10H,1H3

Upstream product

• 100-09-4 4-methoxybenzoic acid 
• 108-95-2 phenol 
• 102-09-0 bis(phenyl) carbonate 
• 59658-06-9 4-methoxybenzoic acid 2-pyridinyl ester 
• 201230-82-2 carbon monoxide 
• 1879-16-9 1-methoxy-4-methylsulfanyl-benzene 
• 123-11-5 4-methoxy-benzaldehyde 
• 696-62-8 para-iodoanisole 
• 50978-45-5 3-oxobenzo[d]isothiazole-2(3H)-carbaldehyde 1,1-dioxide 
• 19501-58-7 4-methoxyphenylhydrazine hydrochloride 
• 104-88-1 4-chlorobenzaldehyde 
• 15226-74-1 dicobalt octacarbonyl 
• 66107-29-7 4-methoxyphenyl triflate 
• 150-76-5 4-methoxy-phenol 

Downstream Products

• 55849-35-9 1-oxo-2-(4-methoxybenzoyl)indane 
• 611-99-4 4,4'-Dihydroxybenzophenone 
• 63084-03-7 6-methoxy-2-[(4-methoxyphenyl)carbonyl]-2,3,4-trihydronaphthalen-1-one 
• 121-98-2 methyl 4-methoxybenzoate 
• 61002-54-8 4-hydroxy-4'-methoxybenzophenone 
• 18733-07-8 (2-hydroxyphenyl)(4-methoxyphenyl)methanone 
• 90-96-0 bis(p-methoxyphenyl)methanone 
• 10355-12-1 1-(4-methoxyphenyl)-4-(trifluoromethyl)benzene 
• 6185-76-8 (4-methoxyphenyl)(4-(trifluoromethyl)phenyl)methanone 
• 7465-88-5 4-methoxy-N-phenylbenzamide 
• 23886-71-7 4-methoxy-4'-methylbenzophenone 
• 874-90-8 4-methoxybenzonitrile 
• 75059-30-2 3,5-bis(4-methoxiphenyl)-1H-pyrazole 
• 37613-37-9 3-(4-fluorophenyl)-5-(4-methoxyphenyl)-1H-pyrazole 

Relevant articles and documents

Transesterification kinetics investigation of r-substituted phenyl benzoates with 4-methoxyphenol in the presence of K2CO3 in DMF

Transesterification of R-substituted phenyl benzoates 1-5 with 4-methoxyphenol 6 was kinetically investigated in the presence of K 2CO3 in dimethylformamide (DMF) at various temperatures. The Hammett plots for the reactions of the 1-

Palladium Catalyzed Regioselective Cyclization of Arylcarboxylic Acids via Radical Intermediates with Diaryliodonium Salts

Palladium-catalyzed C2-arylation/intramolecular acylation with arylcarboxylic acids was developed by using diaryliodonium salts. The protocol has the advantage of good step-economy by two chemical bonds formation in one pot.

Hydrogen-bond-assisted transition-metal-free catalytic transformation of amides to esters

The amide C-N cleavage has drawn a broad interest in synthetic chemistry, biological process and pharmaceutical industry. Transition-metal, luxury ligand or excess base were always vital to the transformation. Here, we developed a transition-metal-free hydrogen-bond-assisted esterification of amides with only catalytic amount of base. The proposed crucial role of hydrogen bonding for assisting esterification was supported by control experiments, density functional theory (DFT) calculations and kinetic studies. Besides broad substrate scopes and excellent functional groups tolerance, this base-catalyzed protocol complements the conventional transition-metal-catalyzed esterification of amides and provides a new pathway to catalytic cleavage of amide C-N bonds for organic synthesis and pharmaceutical industry. [Figure not available: see fulltext.]