41819-49-2

Basic information

• Product Name: 1H-Pyrrole, 2-[3-(trifluoromethyl)phenyl]-
• CAS NO: 41819-49-2
• Molecular Formula: C11H8F3N
• Molecular Weight: 211.186
• Mol File: 41819-49-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole, 2-[3-(trifluoromethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole, 2-[3-(trifluoromethyl)phenyl]-(41819-49-2)
• EPA Substance Registry System: 1H-Pyrrole, 2-[3-(trifluoromethyl)phenyl]-(41819-49-2)

Safety Data

• Hazardous Substances Data: 41819-49-2(Hazardous Substances Data)

Usage

Structure

A derivative of pyrrole with a trifluoromethyl group attached to a phenyl ring

Usage

Commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals

Applications

Potential applications in materials science and organic electronics due to its unique chemical and electronic properties

Medicinal chemistry

Implicated in studies related to the development of new drugs and treatments

Versatility

An important compound with various potential applications in different fields

Upstream product

• 842123-89-1 3-[1,3]Dioxolan-2-yl-1-(3-trifluoromethyl-phenyl)-propan-1-one 
• 116332-62-8 N-methoxy-N-methyl-3-trifluoromethylbenzamide 
• 368-77-4 3-trifluoromethylbenzonitrile 
• 166312-47-6 4-Oxo-4-(3-trifluoromethyl-phenyl)-butyraldehyde 

Relevant articles and documents

Convenient access to 2-arylpyrroles from 2-lithio-N,N- dibenzylcyclopropylamine and nitriles

N,N-Dibenzylaminocyclopropyl ketimines formed as intermediates upon treatment of 2-lithiated N,N-dibenzylcyclopropylamines with nitriles, being donor-acceptor-substituted cyclopropanes, immediately underwent ring-enlarging rearrangement and 1,2-elimination of dibenzylamine to produce 2-substituted pyrroles in good yields (14 examples, 55-80%). Georg Thieme Verlag Stuttgart.

NEW METHODS FOR THE SYNTHESIS OF 2-ARYLPYRROLES

Two short and efficient synthetic approaches for -mostly unknown- 2-arylpyrroles are presented.The key intermediates 3 are conveniently obtained from commercially available acetophenones 5 (method I) or benzoic acid derivatives 10, 11 (method II).