41863-49-4Relevant articles and documents
Gold(i) thiolates containing amino acid moieties. Cytotoxicity and structure-activity relationship studies
Gutirrez, Alejandro,Gracia-Fleta, Lucia,Marzo, Isabel,Cativiela, Carlos,Laguna, Antonio,Gimeno, M. Concepcin
, p. 17054 - 17066 (2014)
Several gold(i) complexes containing a thiolate ligand functionalised with several amino acid or peptide moieties of the type [Au(SPyCOR)(PPh2R′)] (where R = OH, amino acid or dipeptide and R′ = Ph or Py) were prepared. These thiolate gold comp
N-Terminal Selective C?H Azidation of Proline-Containing Peptides: a Platform for Late-Stage Diversification
Allouche, Emmanuelle M. D.,Simonet-Davin, Rapha?l,Waser, Jerome
supporting information, (2022/02/25)
A methodology for the C?H azidation of N-terminal proline-containing peptides was developed employing only commercially available reagents. Peptides bearing a broad range of functionalities and containing up to 6 amino acids were selectively azidated at the carbamate-protected N-terminal residue in presence of the numerous other functional groups present on the molecules. Post-functionalizations of the obtained aminal compounds were achieved: cycloaddition reactions or C?C bond formations via a sequence of imine formation/nucleophilic addition were performed, offering an easy access to diversified peptides.
STAT DEGRADERS AND USES THEREOF
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Paragraph 00841; 00842, (2021/09/26)
The present invention provides compounds, compositions thereof, and methods of using the same.
The Study of Stability of Proline-Containing Derivatives of Dopamine and Serotonin in the Biological Media in Vitro Experiments
Andreeva, L. A.,Myasoedov, N. F.,Nagaev, I. Yu.,Shevchenko, K. V.,Shevchenko, V. P.
, p. 150 - 158 (2020/05/28)
Abstract—: The peptides Boc-Gly-Pro-DP, Z-Gly-Pro-DP, LA-Gly-Pro-DP, Boc-Gly-Pro-Srt, Z-Gly-Pro-Srt have been synthesized for the first time. The study of their stability in the presence of leucine aminopeptidase, carboxypeptidase Y, carboxypeptidase B, and proline endopeptidase (PEP) has shown that the synthesized peptides are stable in the presence of aminopeptidases and carboxypeptidases. In the presence of PEP, dopamine (DP) and serotonin (Srt) have been cleaved from these substances. Thus, the originally synthesized proline derivatives of Srt and DP may be considered as the resources, from which Srt and DP can be gradually released. This creates the possibility of a prolonged action of these biologically active compounds on cells and, consequently, on the whole body.