4187-54-6

Basic information

• Product Name: (S)-N-[1-(4-nitrophenyl)ethyl]acetamide
• Synonyms: (S)-N-[1-(4-nitrophenyl)ethyl]acetamide
• CAS NO: 4187-54-6
• Molecular Weight: 208.217
• Mol File: 4187-54-6.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: (S)-N-[1-(4-nitrophenyl)ethyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-[1-(4-nitrophenyl)ethyl]acetamide(4187-54-6)
• EPA Substance Registry System: (S)-N-[1-(4-nitrophenyl)ethyl]acetamide(4187-54-6)

Safety Data

• Hazardous Substances Data: 4187-54-6(Hazardous Substances Data)

Usage

Description

(S)-N-[1-(4-nitrophenyl)ethyl]acetamide is a chemical compound characterized by its molecular formula C10H12N2O3. It is an amide derivative featuring an acetamide functional group and a nitrophenyl group. This chiral compound has the (S) stereochemistry at the nitrogen atom, which is significant for its potential applications in various fields.

Uses

Used in Pharmaceutical Synthesis:
(S)-N-[1-(4-nitrophenyl)ethyl]acetamide is utilized as an intermediate in the synthesis of a range of pharmaceutical compounds. Its unique structure and functional groups make it a valuable building block for creating new drugs and medicines.
Used in Research and Development:
(S)-N-[1-(4-nitrophenyl)ethyl]acetamide also serves as an important reagent in the field of research and development. It can be used to study the properties and interactions of various chemical and biological systems, contributing to the advancement of scientific knowledge.
Used in Industrial Processes:
(S)-N-[1-(4-nitrophenyl)ethyl]acetamide may find applications in different industrial processes, where its specific chemical characteristics can be harnessed for the production of various products.
Safety Precautions:
It is crucial to handle (S)-N-[1-(4-nitrophenyl)ethyl]acetamide with care, as it may possess hazardous properties. Proper safety measures should be taken to minimize risks during its use in research, pharmaceutical synthesis, and industrial applications.

Upstream product

• 42142-15-4 1-(4-nitro-phenyl)-ethylamine 
• 1434603-08-3 (Z)-1-(4-nitrophenyl)ethanone O-benzyloxime 
• 73744-35-1 (Z)-1-(4-nitrophenyl)ethanone oxime 
• 99-81-0 4-Nitrophenacyl bromide 
• 4187-53-5 (R)-2-methyl-p-nitrobenzylamine 
• 108-24-7 acetic anhydride 
• 100-19-6 (4-nitrophenyl)ethanone 
• 108-21-4 Isopropyl acetate 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 36283-44-0 N-acetyl-1-phenylethylamine 
• 1121583-62-7 isopropyl 2-propoxyacetate 
• 4187-53-5 (S)-1-(p-nitrophenyl)ethylamine 
• 2354-91-8 (S)-2,2,2-trifluoro-(α-methylbenzyl)acetamide 
• 19144-86-6 (S)-N-acetyl-1-phenylethylamine 

Downstream Products

• 100253-60-9 (R)-1-acetylamino-4-(1-acetylamino-ethyl)-benzene 
• 4187-53-5 (R)-2-methyl-p-nitrobenzylamine 
• 103214-07-9 (-)-N-acetyl-α-(p-N'-picrylaminophenyl)ethylamine 
• 103214-07-9 (+)-N-acetyl-α-(p-N'-picrylaminophenyl)ethylamine 
• 4187-53-5 (S)-1-(p-nitrophenyl)ethylamine 
• 92779-77-6 (R)-N-(1-(4-aminophenyl)ethyl)acetamide 

Relevant articles and documents

New chiral ferrocene/indole-based diphosphine ligands for Rh-catalyzed asymmetric hydrogenation of functionalized olefins

Convenient synthesis of a new family of chiral ferrocene/indole-based diphosphine ligands, (Rc,Rp)-IndoFerroPhos (L), from (Sc,Rp)-PPFA and 2-(diphenylphosphino)indole has been described. These new ligands exhibited high efficiency in the Rh-catalyzed asymmetric hydrogenation of functionalized olefins including α-dehydroamino acid esters, α-enamides and dimethyl itaconate, in which up to >99% yield and 98% ee were achieved.

Quinazoline derivatives and its preparation method and application

The invention relates to quinazoline derivatives and its preparation method and application. The quinazoline derivatives with The structural formula, the quinazoline derivative to gefitinib for the positive control, the result shows that compared with the gefitinib has good activity; and lead compound OTS514 compared, equivalent activity, PBK/TOPK inhibitors for further transformation and the discovery of new anti-tumor medicine phenological shopping has higher learning with the reference value. The invention also provides a preparation method of the quinazoline derivatives and the preparation of PBK/TOPK inhibitor and an anticancer drug.

Optimization of 2-alkoxyacetates as acylating agent for enzymatic kinetic resolution of chiral amines

In this study, the activity of acetic acid esters modified with electron withdrawing 2-alkoxy-groups was investigated as acylating agent in kinetic resolution (KR) of racemic amines. A homologous series of the isopropyl esters of four 2-alkoxyacetic acids (2-methoxy-, 2-ethoxy-, 2-propoxy- and 2-butoxyacetic acids) were prepared and investigated for enantiomer selective N-acylation, catalyzed by lipase B from Candida antarctica, under batch and continuous-flow conditions. In the first set of experiments, isopropyl 2-propoxyacetate showed the highest effectivity with all of the four racemic amines [(±)-1-phenylethylamine, (±)-4-phenylbutan-2-amine, (±)-heptan-2-amine and (±)-1-methoxypropane-2-amine] in the set enabling excellent conversions (≥46%) and enantiomeric excess values (ee ≥ 99%) with each amines in continuous-flow mode KRs under the optimized reaction conditions. In a second set of experiments, KRs of five additional amines – being substituted derivatives of (±)-1-phenylethylamine – further demonstrated the usefulness of isopropyl 2-propoxyacetate – being the best acylating agent in the first set of KRs – in KRs leading to (R)-N-propoxyacetamides with high ee values (≥99.8%).