418762-89-7

Basic information

• Product Name: 2-chloro-6-(1H-pyrrol-1-yl)benzonitrile
• Synonyms: 2-chloro-6-(1H-pyrrol-1-yl)benzonitrile
• CAS NO: 418762-89-7
• Molecular Weight: 202.643
• Mol File: 418762-89-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-chloro-6-(1H-pyrrol-1-yl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-6-(1H-pyrrol-1-yl)benzonitrile(418762-89-7)
• EPA Substance Registry System: 2-chloro-6-(1H-pyrrol-1-yl)benzonitrile(418762-89-7)

Safety Data

• Hazardous Substances Data: 418762-89-7(Hazardous Substances Data)

Upstream product

• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 6575-11-7 2-amino-6-chlorobenzonitrile 
• 3320-90-9 2,5-diethoxytetrahydrofurane 

Downstream Products

• 418762-88-6 2-(1H-pyrrol-1-yl)-6-chlorobenzylamine 
• 866042-57-1 (2-Chloro-6-pyrrol-1-yl-benzyl)-[1-(4-ethyl-phenyl)-meth-(E)-ylidene]-amine 
• 1352144-70-7 C₂₀H₁₇ClF₂N₂O 
• 1352144-75-2 C₂₀H₁₆ClF₃N₂O 

Relevant articles and documents

Driving Recursive Dehydration by PIII/PV Catalysis: Annulation of Amines and Carboxylic Acids by Sequential C-N and C-C Bond Formation

A method for the annulation of amines and carboxylic acids to form pharmaceutically relevant azaheterocycles via organophosphorus PIII/PV redox catalysis is reported. The method employs a phosphetane catalyst together with a mild bromenium oxidant and terminal hydrosilane reductant to drive successive C-N and C-C bond-forming dehydration events via the serial action of a catalytic bromophosphonium intermediate. These results demonstrate the capacity of PIII/PV redox catalysis to enable iterative redox-neutral transformations in complement to the common reductive driving force of the PIII/PV couple.

NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]- BENZODIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH BICYCLIC BENZENE DERIVATIVES

The present invention is concerned with novel antifungal 5,6-dihydro-4H-pyrrolo- [1,2-a][1,4]benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with bicyclic benzene derivatives of Formula (I) wherein R1, R2, Rsup

Pyrrolo[1,2-a][1,4]benzodiazepine: A novel class of non-azole anti-dermatophyte anti-fungal agents

Broad screening revealed compound 1a to be a novel anti-fungal agent with high specificity towards dermatophytes. The anti-fungal structure-activity relationship of this novel class of 5,6-dihydro-4H-pyrrolo[1,2-a][1,4] benzodiazepines is described togeth