4192-14-7 Usage
Description
O-(4-hydroxy-3,5-diiodophenyl)-L-tyrosine, also known as 3',5'-diiodo-L-thyronine, is a derivative of the thyroid hormone thyroxine (T4) with a modified side chain. It possesses the characteristic structure of a thyroid hormone, including the hydroxylated phenyl ring and the diiodinated side chain, which are essential for its biological activity. This molecule plays a crucial role in regulating various metabolic processes in the body.
Uses
Used in Pharmaceutical Industry:
O-(4-hydroxy-3,5-diiodophenyl)-L-tyrosine is used as a pharmaceutical agent for its potential therapeutic effects on lipid metabolism. It has been shown to increase the activity of malic enzyme and glucose-6-phosphate dehydrogenase in teleost Anabas testudineus, indicating its short-term effects on lipid metabolism. This property makes it a promising candidate for the development of drugs targeting metabolic disorders and thyroid-related conditions.
Used in Research Applications:
In addition to its potential pharmaceutical applications, O-(4-hydroxy-3,5-diiodophenyl)-L-tyrosine is also used as a research tool in the study of thyroid hormone action and metabolism. It can be employed in various in vitro and in vivo experiments to investigate the mechanisms underlying the regulation of lipid metabolism and other physiological processes influenced by thyroid hormones.
Used in Diagnostic Applications:
O-(4-hydroxy-3,5-diiodophenyl)-L-tyrosine may also find use in the development of diagnostic tools for thyroid disorders. Its unique structure and biological activity can be exploited to create assays or tests that help in the detection and monitoring of thyroid hormone levels and related metabolic imbalances.
Check Digit Verification of cas no
The CAS Registry Mumber 4192-14-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,1,9 and 2 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 4192-14:
(6*4)+(5*1)+(4*9)+(3*2)+(2*1)+(1*4)=77
77 % 10 = 7
So 4192-14-7 is a valid CAS Registry Number.
InChI:InChI=1/C15H13I2NO4/c16-11-6-10(7-12(17)14(11)19)22-9-3-1-8(2-4-9)5-13(18)15(20)21/h1-4,6-7,13,19H,5,18H2,(H,20,21)/t13-/m0/s1
4192-14-7Relevant articles and documents
Remarkable Effect of Chalcogen Substitution on an Enzyme Mimetic for Deiodination of Thyroid Hormones
Raja, Karuppusamy,Mugesh, Govindasamy
supporting information, p. 7674 - 7678 (2015/06/25)
Iodothyronine deiodinases are selenoenzymes which regulate the thyroid hormone homeostasis by catalyzing the regioselective deiodination of thyroxine (T4). Synthetic deiodinase mimetics are important not only to understand the mechanism of enzyme catalysis, but also to develop therapeutic agents as abnormal thyroid hormone levels have implications in different diseases, such as hypoxia, myocardial infarction, critical illness, neuronal ischemia, tissue injury, and cancer. Described herein is that the replacement of sulfur/selenium atoms in a series of deiodinase mimetics by tellurium remarkably alters the reactivity as well as regioselectivity toward T4. The tellurium compounds reported in this paper represent the first examples of deiodinase mimetics which mediate sequential deiodination of T4 to produce all the hormone derivatives including T0 under physiologically relevant conditions.
