42018-09-7

Basic information

• Product Name: ethyl (4-acetyl-2-methylphenoxy)acetate
• CAS NO: 42018-09-7
• Molecular Formula: C₁₃H₁₆O₄
• Molecular Weight: 236.2637
• Mol File: 42018-09-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 358.642°C at 760 mmHg
• Flash Point: 157.913°C
• Density: 1.103g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.504
• CAS DataBase Reference: ethyl (4-acetyl-2-methylphenoxy)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (4-acetyl-2-methylphenoxy)acetate(42018-09-7)
• EPA Substance Registry System: ethyl (4-acetyl-2-methylphenoxy)acetate(42018-09-7)

Safety Data

• Hazardous Substances Data: 42018-09-7(Hazardous Substances Data)

Upstream product

• 876-02-8 4-hydroxy-3-methylphenyl methyl ketone 
• 105-39-5 chloroacetic acid ethyl ester 
• 533-18-6 2-methylphenyl acetate 
• 93917-68-1 ethyl (2-methylphenoxy)acetate 
• 75-36-5 acetyl chloride 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 1268705-00-5 (E)-ethyl 2-(4-(1-(hydroxyimino)ethyl)-2-methylphenoxy)acetate 
• 1268705-13-0 (E)-(2-methyl-4-{1-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxyimino]-ethyl}-phenoxy)-acetic acid ethyl ester 
• 1268705-19-6 (E)-(2-methyl-4-{1-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxyimino]-ethyl}-phenoxy)-acetic acid 
• 1268705-26-5 (E)-ethyl 2-(2-methyl-4-(1-(((5-methyl-2-phenyloxazol-4-yl)methoxy)imino)ethyl)phenoxy)acetate 
• 1268705-33-4 (E)-ethyl 2-(2-methyl-4-(1-(((5-methyl-2-(p-tolyl)oxazol-4-yl)methoxy)imino)ethyl)phenoxy)acetate 
• 1268705-39-0 (E)-2-(2-methyl-4-(1-(((5-methyl-2-phenyloxazol-4-yl)methoxy)imino)ethyl)phenoxy)acetic acid 
• 1268705-46-9 (E)-2-(2-methyl-4-(1-(((5-methyl-2-(p-tolyl)oxazol-4-yl)methoxy)imino)ethyl)phenoxy)acetic acid 
• 403612-14-6 (4-hydroxy-2-methylphenoxy)acetic acid ethyl ester 
• 1207268-78-7 ethyl 2-(2-methyl-4-(1-(3-(4-methyl-5-oxo-1-(4-trifluoromethyl-phenyl)-4,5-dihydrogen-1H-1,2,4-triazolyl))-benzyloxy)-phenoxy)-acetate 
• 1207268-97-0 2-(2-methyl-4-(1-(3-(4-methyl-5-oxo-1-(4-trifluoromethyl-phenyl)-4,5-dihydrogen-1H-1,2,4-triazolyl))-benzyloxy)-phenoxy)-acetic acid 
• 476155-17-6 (4-acetoxy-2-methyl-phenoxy)-acetic acid ethyl ester 

Relevant articles and documents

Effect of structurally constrained oxime-ether linker on PPAR subtype selectivity: Discovery of a novel and potent series of PPAR-pan agonists

A novel series of thaizole and oxazole containing phenoxy acetic acid derivatives is reported as PPAR-pan agonists. Incorporation of structurally constrained oxime-ether based linker in the chemotype of a potent PPARδ selective agonist GW-501516 was adapted as designing strategy. In vitro, selected test compounds 12a, 12c, 17a and 18a showed PPAR-pan agonists activities and among these four compounds tested, 12a emerged as highly potent and efficacious compound, while 17a exhibited moderate and balanced PPAR-pan agonistic activity. In vivo, selected test compounds 12a and 17a exhibited significant anti-hyperglycemic and anti-hyperlipidemic activities in relevant animal models. These results support our hypothesis that the introduction of structurally constrained oxime-ether linker between lipophilic tail and acidic head plays an important role in modulating subtype selectivity and subsequently led to the discovery of potent PPAR-pan agonists.

GPR120 RECEPTOR AGONISTS AND USES THEREOF

GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.

GPR120 RECEPTOR AGONISTS AND USES THEREOF

GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.