42024-93-1

Basic information

• Product Name: 2-AMINO-3-BENZOYL-4,5-DIMETHYLTHIOPHENE
• Synonyms: 2-AMINO-3-BENZOYL-4,5-DIMETHYLTHIOPHENE;(2-Amino-4,5-dimethyl-3-thienyl)phenyl ketone;Phenyl(2-amino-4,5-dimethyl-3-thienyl) ketone;Phenyl(2-amino-4-methyl-5-methyl-3-thienyl) ketone;(2-Amino-4,5-dimethyl-thiophen-3-yl)-phenyl-methanone;(2-amino-4,5-dimethylthiophen-3-yl)-phenylmethanone
• CAS NO: 42024-93-1
• Molecular Formula: C₁₃H₁₃NOS
• Molecular Weight: 231.31
• Mol File: 42024-93-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 401.2 °C at 760 mmHg
• Flash Point: 196.4 °C
• Appearance: /
• Density: 1.205 g/cm³
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2-AMINO-3-BENZOYL-4,5-DIMETHYLTHIOPHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-3-BENZOYL-4,5-DIMETHYLTHIOPHENE(42024-93-1)
• EPA Substance Registry System: 2-AMINO-3-BENZOYL-4,5-DIMETHYLTHIOPHENE(42024-93-1)

Safety Data

• Hazardous Substances Data: 42024-93-1(Hazardous Substances Data)

Usage

General Description

2-Amino-3-benzoyl-4,5-dimethylthiophene is a chemical compound containing a thiophene ring with an attached benzoyl and amino group, as well as two methyl groups. It is commonly used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and organic materials due to its unique structure and reactivity. 2-AMINO-3-BENZOYL-4,5-DIMETHYLTHIOPHENE has been studied for its potential anticancer and antimicrobial properties, and its derivatives have shown promise as potential drug candidates. Additionally, it is also used as a building block in the production of dyes, pigments, and other specialty chemicals.

Upstream product

• 614-16-4 Benzoylacetonitrile 
• 78-93-3 butanone 
• 110-91-8 morpholine 
• 565-80-0 2,4-dimethylpentan-3-one 
• 51948-20-0 N-(4,5-dimethyl-thiophen-2-yl)acetamide 
• 5834-16-2 3-methyl-2-thiophenecarboxaldehdye 
• 632-16-6 2,3-dimethylthiophene 
• 399043-17-5 N-(3-benzoyl-4,5-dimethyl-thiophen-2-yl)acetamide 

Downstream Products

• 77132-58-2 (5,6-Dimethyl-2-methylsulfanyl-4-phenyl-4H-thieno[2,3-d]pyrimidin-3-yl)-acetic acid ethyl ester; hydriodide 
• 77132-52-6 3-benzyl-5,6-dimethyl-2-methylthio-4-phenyl-3,4-dihydrothieno<2,3-d>pyrimidine hydroiodide 
• 77132-56-0 (5,6-Dimethyl-4-phenyl-thieno[2,3-d]pyrimidin-2-ylamino)-acetic acid ethyl ester 
• 77132-49-1 ethyl 2-chloro-5,6-dimethyl-4-phenyl-3,4-dihydrothieno<2,3-d>pyrimidine-3-acetate 
• 77132-47-9 (5,6-Dimethyl-4-phenyl-2-thioxo-1,4-dihydro-2H-thieno[2,3-d]pyrimidin-3-yl)-acetic acid ethyl ester 
• 77132-45-7 ethyl 5,6-dimethyl-2-oxo-4-phenyl-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate 
• 77132-46-8 3-Benzyl-5,6-dimethyl-4-phenyl-3,4-dihydro-1H-thieno[2,3-d]pyrimidine-2-thione 
• 77132-60-6 2-benzylamino-5,6-dimethyl-4-phenylthieno<2,3-d>pyrimidine 
• 77132-57-1 (5,6-dimethyl-4-phenylthieno<2,3-d>pyrimidin-2-ylamino)acetamide 
• 77132-54-8 6,7-dimethyl-5-phenyl-1,2,3,5-tetrahydroimidazo<1,2-a>thieno<2,3-d>pyrimidin-2-one 
• 77132-48-0 2-chloro-5,6-dimethyl-4-phenyl-3,4-dihydrothieno<2,3-d>pyrimidine 
• 77132-55-9 2-amino-5,6-dimethyl-4-phenylthieno<2,3-d>pyrimidine 
• 77139-83-4 2-chloro-5,6-dimethyl-4-phenylthieno<2,3-d>pyrimidine 
• 77132-44-6 5,6-dimethyl-4-phenyl-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidin-2-one 

Relevant articles and documents

6H-THIENO[2,3-E][1,2,4]TRIAZOLO[3,4-C][1,2,4]TRIAZEPINE DERIVATIVE

The 6H-thieno[2,3-e][1,2,4]triazolo[3,4-c][1,2,4]triazepine derivatives or salts thereof of the present invention have BRD4 inhibitory activity, and thus, they are useful as medicaments, in particular, as prophylaxis and/or therapeutic agents for diseases associated with BRD4.

THIENO-PYRIDINE DERIVATIVES AS GABA-B ALLOSTERIC ENHANCERS

The present invention relates to compounds of formula (I), Wherein R1 to R5 are as defined in the specification which compounds are active on the GABABreceptor and can be used for the manufacture of medicaments useful for treating CNS disorders.

2-Amino-3-aroyl-4,5-alkylthiophenes: Agonist allosteric enhancers at human a1 adenosine receptors

2-Amino-3-benzoylthiophenes are allosteric enhancers (AE) of agonist activity at the A1 adenosine receptor. The present report describes syntheses and assays of the AE activity at the human A1AR (hA1AR) of a panel of compounds consisting of nine 2-amino-3-aroylthiophenes (3a-i), eight 2-amino-3-benzoyl-4,5-dimethylthiophenes (12a-h), three 3-aroyl-2-carboxy-4,5-dimethylthiophenes (15a-c), 10 2-amino-3-benzoyl-5,6-dihydro-4H-cyclopenta[b]thiophenes (17a-j), 14 2-amino-3-benzoyl-4,5,6,7-tetrahydrobenzo[b]thiophenes (18a-n), and 15 2-amino-3-benzoyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophenes (19a-o). An in vitro assay employing the A1AR agonist [125I]ABA and membranes from CHO-K1 cells stably expressing the hA1AR measured, as an index of AE activity, the ability of a candidate AE to stabilize the agonist-A1AR-G protein ternary complex. Compounds 3a-i had little or no AE activity, and compounds 12a-h had only modest activity, evidence that AE activity depended absolutely on the presence of at least a methyl group at C-4 and C-5. Compounds 17a-c lacked AE activity, suggesting the 2-amino group is essential. Polymethylene bridges linked thiophene C-4 and C-5 of compounds 17a-j, 18a-n, and 19a-o. AE activity increased with the size of the -(CH2)n- bridge, n = 3 1AR contains an allosteric binding site able to accommodate 3-aroyl substituents that are bulky and/or hydrophobic but not necessarily planar. A second region in the allosteric binding site interacts constructively with alkyl substituents at thiophene C-4 and/or C-5.