42059-81-4 Usage
Description
3-Formyl-6-methylchromone is a 3-formyl-substituted chromone, which is a yellow powder. It has been studied for its enthalpy of combustion and its anti-proliferative action on the MDR human colon cancer and mouse lymphoma.
Uses
Used in Pharmaceutical Industry:
3-Formyl-6-methylchromone is used as a chemical intermediate for the preparation of a series of Schiff's bases. These bases are synthesized through a reaction with aromatic sulfonamides, such as sulfanilamide, homosulfanilamide, 4-aminoethyl-benzenesulfonamide, a pyrimidinyl-substituted sulfanilamide derivative, sulfaguanidine, and 4-amino-6-trifluoromethyl-benzene-1,3-disulfonamide. The Schiff base prepared from 3-formyl-6-methylchromone can undergo an addition reaction with diethyl phosphite, leading to the formation of bis[(1,2,4,3-triazaphospholyl)(chromonyl)aminomethylphosphonate] derivative and bis[(1,2,4,3-triazaphospholyl)(chromonyl)phosphorylamino-methylphosphonate] derivative. These compounds have potential applications in the development of new drugs and pharmaceuticals.
Used in Chemical Research:
3-Formyl-6-methylchromone serves as a valuable compound for researchers in the field of organic chemistry. Its unique structure and properties make it a useful starting material for the synthesis of various complex organic molecules and for studying the chemical reactions and mechanisms involved in their formation.
Check Digit Verification of cas no
The CAS Registry Mumber 42059-81-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,0,5 and 9 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 42059-81:
(7*4)+(6*2)+(5*0)+(4*5)+(3*9)+(2*8)+(1*1)=104
104 % 10 = 4
So 42059-81-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H8O3/c1-7-2-3-10-9(4-7)11(13)8(5-12)6-14-10/h2-6H,1H3
42059-81-4Relevant articles and documents
Design and synthesis of chromone-nitrogen mustard derivatives and evaluation of anti-breast cancer activity
Sun, Jianan,Mu, Jiahui,Wang, Shenglin,Jia, Cai,Li, Dahong,Hua, Huiming,Cao, Hao
, p. 431 - 444 (2022/01/04)
Chromone has emerged as one of the most important synthetic scaffolds for antitumor activity, which promotes the development of candidate drugs with better activity. In this study, a series of nitrogen mustard derivatives of chromone were designed and syn
Chromone 3-position nitric oxide donor derivative as well as preparation method and application thereof
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Paragraph 0024-0026, (2021/05/05)
The invention relates to the fields of natural medicines and medicinal chemistry, and relates to a preparation method of a series of chromone 3-position nitric oxide donor derivatives with antitumor activity and a new application of the chromone 3-position nitric oxide donor derivatives in preparation of antitumor medicines. The chromone 3-position nitric oxide donor derivative and the pharmaceutically acceptable salt thereof are shown as a general formula I in the specification. Wherein R and R1 are described in the claims and the specification.
Chromone 2-position nitric oxide donor derivative as well as preparation method and application thereof
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Paragraph 0021-0023, (2021/05/05)
The invention relates to the fields of natural medicines and medicinal chemistry, and relates to a preparation method of a series of chromone 2-position nitric oxide donor derivatives with antitumor activity and a new application of the chromone 2-position nitric oxide donor derivatives in preparation of antitumor medicines. The chromone 2-position nitric oxide donor derivative and the pharmaceutically acceptable salt thereof are shown as a general formula I in the specification. Wherein R and R1 are described in the claims and the specification.
