42060-83-3

Basic information

• Product Name: BIPHENYL-4-YL-PIPERIDIN-4-YL-METHANONE
• Synonyms: BIPHENYL-4-YL-PIPERIDIN-4-YL-METHANONE;Biphneyl-4-yl-piperidin-4-yl-methanone;[1,1'-Biphenyl]-4-yl 4-piperidinyl methanone;Biphenyl-4-yl-4-piperidinyl-methanone HCl;Methanone, [1,1'-biphenyl]-4-yl-4-piperidinyl-
• CAS NO: 42060-83-3
• Molecular Formula: C₁₈H₁₉NO
• Molecular Weight: 265.35
• Mol File: 42060-83-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 428.5 °C at 760 mmHg
• Flash Point: 155.5 °C
• Appearance: /
• Density: 1.084 g/cm³
• Vapor Pressure: 1.51E-07mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: BIPHENYL-4-YL-PIPERIDIN-4-YL-METHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: BIPHENYL-4-YL-PIPERIDIN-4-YL-METHANONE(42060-83-3)
• EPA Substance Registry System: BIPHENYL-4-YL-PIPERIDIN-4-YL-METHANONE(42060-83-3)

Safety Data

• Hazardous Substances Data: 42060-83-3(Hazardous Substances Data)

Usage

General Description

BIPHENYL-4-YL-PIPERIDIN-4-YL-METHANONE is a chemical compound that consists of a piperidine ring substituted at the 4-position with a biphenyl group and a ketone group at the 4-position of the piperidine ring. It is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. BIPHENYL-4-YL-PIPERIDIN-4-YL-METHANONE has potential applications in the pharmaceutical industry, especially in the development of drugs targeting various biological pathways. Additionally, it may have utility in the field of medicinal chemistry, where it could be used as a building block for the creation of novel drug candidates. Due to its structural features, BIPHENYL-4-YL-PIPERIDIN-4-YL-METHANONE is of interest to researchers and chemists for its diverse range of potential applications.

InChI:InChI=1/C18H19NO/c20-18(17-10-12-19-13-11-17)16-8-6-15(7-9-16)14-4-2-1-3-5-14/h1-9,17,19H,10-13H2

Upstream product

• 53220-41-0 4-(4-chlorobenzoyl)piperidine 
• 209808-06-0 tert-butyl 4-(4-chlorobenzoyl)piperidine-1-carboxylate 

Downstream Products

• 64671-37-0 biphenyl-4-yl-[1-(2-indol-3-yl-ethyl)-piperidin-4-yl]-methanone 

Relevant articles and documents

Structural Optimization of 4-Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors

Monoacylglycerol lipase (MAGL) inhibitors are considered potential therapeutic agents for a variety of pathological conditions, including several types of cancer. Many MAGL inhibitors are reported in literature; however, most of them showed an irreversible mechanism of action, which caused important side effects. The use of reversible MAGL inhibitors has been only partially investigated so far, mainly because of the lack of compounds with good MAGL reversible inhibition properties. In this study, starting from the (4-(4-chlorobenzoyl)piperidin-1-yl)(4-methoxyphenyl)methanone (CL6a) lead compound that showed a reversible mechanism of MAGL inhibition (Ki = 8.6 μM), we started its structural optimization and we developed a new potent and selective MAGL inhibitor (17b, Ki = 0.65 μM). Furthermore, modeling studies suggested that the binding interactions of this compound replace a structural water molecule reproducing its H-bonds in the MAGL binding site, thus identifying a new key anchoring point for the development of new MAGL inhibitors.