4209-02-3

Basic information

• Product Name: 1-(4-bromophenyl)-2-chloroethan-1-one
• Synonyms: 1-(4-bromophenyl)-2-chloroethan-1-one;2-Chloro-4’4'-Bromo-2-chloroacetophenone;4'-Bromo-α-chloroacetophenone;2-Chloro-4'-bromoacetophenone;p-Bromo-2-chloroacetophenone
• CAS NO: 4209-02-3
• Molecular Formula: C₈H₆BrClO
• Molecular Weight: 233.48964
• EINECS: 224-134-6
• Mol File: 4209-02-3.mol
• Article Data: 46

Chemical Properties

• Melting Point: 119-120 °C
• Boiling Point: 306.7 °C at 760 mmHg
• Flash Point: 139.3 °C
• Appearance: /
• Density: 1.572 g/cm³
• Vapor Pressure: 0.000759mmHg at 25°C
• Refractive Index: 1.571
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 1-(4-bromophenyl)-2-chloroethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-bromophenyl)-2-chloroethan-1-one(4209-02-3)
• EPA Substance Registry System: 1-(4-bromophenyl)-2-chloroethan-1-one(4209-02-3)

Safety Data

• Hazard Codes: Xn
• Hazardous Substances Data: 4209-02-3(Hazardous Substances Data)

Usage

Uses

2-Chloro-4''-bromoacetophenone

InChI:InChI=1/C8H6BrClO/c9-7-3-1-6(2-4-7)8(11)5-10/h1-4H,5H2

Upstream product

• 99-73-0 para-bromophenacyl bromide 
• 99-90-1 para-bromoacetophenone 
• 21757-86-8 1-(4-bromophenyl)-2,2,2-trichloroethan-1-ol 
• 81585-72-0 1-(4-bromo-phenyl)-2-iodo-ethanone 
• 80-11-5 N-methyl-N-nitrosotoluene-p-sulfonamide 
• 586-75-4 4-chlorobenzoyl chloride 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 79-11-8 chloroacetic acid 
• 67-56-1 methanol 
• 619-41-0 4-(bromoacetyl)toluene 
• 94783-77-4 Dimethyl-<4-brom-phenacyl>-sulfoniumchlorid 
• 766-96-1 4-bromo-1-ethynylbenzene 
• 64-19-7 acetic acid 
• 5391-88-8 1-(4-bromophenyl)ethanol 

Downstream Products

• 119730-46-0 2,4-bis(4-bromobenzoylmethylthio)pyrimidin-6-amine 
• 99-90-1 para-bromoacetophenone 
• 111946-84-0 1-(4-Bromo-phenyl)-2-(4-nitro-phenoxy)-ethanone 
• 7500-37-0 2-(4-bromophenyl)-2-oxoethyl acetate 
• 21547-82-0 2-((1H-benzo[d]imidazol-2-yl)thio)-1-(4-bromophenyl)ethan-1-one 
• 65679-14-3 1-(4-bromophenyl)-2-thiocyanatoethanone 
• 3343-45-1 4-bromo-2-hydroxyacetophenone 
• 1209004-01-2 5-(p-bromobenzoyl)-4-methyl-3-(1-pyridino)thiophene-2-thiolate 
• 1434751-77-5 2-benzoyl-4-(4-bromophenyl)-1-phenylbut-2-ene-1,4-dione 
• 1586781-03-4 6-(4-bromophenacyl)-9-hydroxy-2,3,9,10-tetrahydro-8H-[1,4]dioxino[2,3-f][1,3]thiazino[3,2-a]benzimidazolium chloride 
• 56613-81-1 (S)-2-Amino-1-phenyl-1-ethanol 
• 107943-12-4 2-(4-bromophenylamino)-4-(4-bromophenyl)thiazole 
• 325806-73-3 4-(4-bromophenyl)-N-(4-chlorophenyl)thiazol-2-amine 

Relevant articles and documents

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Convergent Synthesis of Immune Inhibitor IMMH002

A convergent synthesis of IMMH002 in 36% overall yield starting from bromobenzene is described with a key Suzuki-Miyaura cross-coupling reaction used to provide a crucial intermediate. The route does not require column chromatography and solves the most intractable quality problem caused by a homologue by-product in the original linear synthesis. Furthermore, reducing the use of Lewis acid mediated reactions improves the environmental impact of the synthesis and reduces overall waste. The new route described herein is more efficient, convenient, reliable, and economically more viable when compared to the previously reported linear route.

Preparation method of pusaimode (Chinese name)

The invention discloses a preparation method of pusaimode. Bromo-benzene is used as an initial raw material to prepare pusaimode by adopting a convergent synthesis route. The yield of the preparationmethod is high, the cost is low, the amount of generated waste water, waste gas, and waste solids is low, the operation is convenient, and the application value is high.