4211-90-9

Basic information

• Product Name: 3-Ethyl-5-phenylisoxazole
• Synonyms: 3-Ethyl-5-phenylisoxazole
• CAS NO: 4211-90-9
• Molecular Formula: C₁₁H₁₁NO
• Molecular Weight: 0
• Mol File: 4211-90-9.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Ethyl-5-phenylisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Ethyl-5-phenylisoxazole(4211-90-9)
• EPA Substance Registry System: 3-Ethyl-5-phenylisoxazole(4211-90-9)

Safety Data

• Hazardous Substances Data: 4211-90-9(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 29, p. 445, 1992 DOI: 10.1002/jhet.5570290225

Upstream product

• 13387-31-0 1-phenyl-1-penten-3-one oxime 
• 108-03-2 1-Nitropropane 
• 536-74-3 phenylacetylene 
• 627-39-4 propionaldehyde oxime 
• 35749-33-8 N-hydroxypropionimidoyl chloride 
• 1262887-07-9 5-ethyl-2,2-dimethyl-4,6-dioxa-1-aza-bicyclo[3.1.0]hexane 
• 87290-97-9 (phenylethynyl)dimethylsilane 
• 87710-79-0 methoxy-dimethyl(phenylethynyl)silane 
• 850131-27-0 3-ethyl-4-(dimethylhydroxysilyl)-5-phenylisoxazole 
• 636-98-6 p-nitrobenzene iodide 
• 7803-49-8 hydroxylamine 
• 19307-74-5 1-phenyl-pent-1-yn-3-one 
• 1027915-84-9 3-Ethyl-5-phenyl-4,5-dihydro-isoxazol-5-ol 
• 93-58-3 benzoic acid methyl ester 

Relevant articles and documents

Rhodium(II)-Catalyzed Formal [3 + 2] Cycloaddition of N-Sulfonyl-1,2,3-triazoles with Isoxazoles: Entry to Polysubstituted 3-Aminopyrroles

A novel rhodium(II)-catalyzed formal [3 + 2] cycloaddition of N-sulfonyl-1,2,3-triazoles with isoxazoles has been achieved that provides an efficient method for the synthesis of polysubstituted 3-aminopyrrole derivatives. An operationally simple one-pot synthesis of the titled compounds from terminal alkynes, tosyl azide, and isoxazoles was also developed. The presented reaction affords an illustrative example of employing 1,2,3-triazoles as the [2C]-component in relevant cycloaddition reactions.

Condensed oxaziridine-mediated [3+2] cycloaddition: Synthesis of polyhetero-bicyclo compounds

Polyhetero-bicyclo compounds were synthesized by a regioselective [3+2]-cycloaddition reaction between stable condensed oxaziridines and alkenes, alkynes, and nitriles. These molecules showed considerable antimicrobial activity against several gram-positive bacteria.

An efficient, scaleable procedure for the conversion of esters to isoxazoles

A concise, regiocontrolled route to isoxazoles, based on the condensation of an ester with a metallated imine, has been developed. The intermediate vinylogous amides react smoothly with hydroxylamine to provide, after dehydration, substituted isoxazoles. The method has been used for the multi-kilo scale preparation of ABT-418, a novel cholinergic channel activator.