4212-49-1

Basic information

• Product Name: 5-Ethyluracil
• Synonyms: 5-ethvluracil;5-Ethyluracil, 98+%;2,4-Dihydroxy-5-ethylpyrimidine, Homothymine;5-ethylpyriMidine-2,4(1H,3H)-dione;HOMOTHYMINE;AURORA KA-580;5-ETHYLURACIL;2,4-DIHYDROXY-5-ETHYLPYRIMIDINE
• CAS NO: 4212-49-1
• Molecular Formula: C₆H₈N₂O₂
• Molecular Weight: 140.14
• EINECS: 443-780-1
• Product Categories: PYRIMIDINE;Heterocycles
• Mol File: 4212-49-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: >300 °C(lit.)
• Appearance: White crystalline powder
• Density: 1.164 g/cm³
• Refractive Index: 1.482
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.21±0.10(Predicted)
• BRN: 119494
• CAS DataBase Reference: 5-Ethyluracil(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Ethyluracil(4212-49-1)
• EPA Substance Registry System: 5-Ethyluracil(4212-49-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 4212-49-1(Hazardous Substances Data)

Usage

Chemical Properties

Solid

InChI:InChI=1/C6H8N2O2/c1-2-4-3-7-6(10)8-5(4)9/h3H,2H2,1H3,(H2,7,8,9,10)

Upstream product

• 56686-16-9 5-bromo-2,4-dimethoxypyrimidine 
• 75-03-6 ethyl iodide 
• 34171-37-4 5-ethyl-2-thiouracil 
• 119749-41-6 2-(2,5-dioxo-imidazolidin-4-ylidene)-butyric acid ethyl ester 
• 36873-42-4 ethyl 2-formylbutanoate 
• 57-13-6 urea 
• 120268-44-2 5-ethyl-6-chloro-2,4-dimethoxypyrimidine 
• 1780-38-7 2,4,6-trichloro-5-ethylpyrimidine 
• 2518-72-1 5-ethyl barbituric acid 
• 134699-96-0 4'-thio-5-ethyl-2'-deoxyuridine 
• 143208-47-3 5-ethyl-6-methanesulphonyloxy-2,4-(1H,3H)-pyrimidinedione 
• 14383-29-0 5-ethylorotic acid 
• 120268-53-3 5-ethyl-2,4-dimethoxypyrimidine 

Downstream Products

• 31703-08-9 1,3-dimethyl-5-ethyluracil 
• 29900-44-5 1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-ribofuranosyl)-5-ethyl-2,4(1H,3H)-pyrimidinedione 
• 29900-45-6 1-(2-deoxy-3,5-di-O-p-toluoyl-α-D-ribofuranosyl)-5-ethyl-2,4(1H,3H)-pyrimidinedione 
• 171721-04-3 1-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-L-arabinofuranosyl)-5-ethyluracil 
• 153562-61-9 5-ethyl-1-(benzyloxymethyl)uracil 
• 294867-76-8 1-[5-(tert-butyl-diphenyl-silanyloxymethyl)-3-fluoro-4-hydroxy-tetrahydro-thiophen-2-yl]-5-ethyl-4-hydroxy-1H-pyrimidin-2-one 
• 294867-74-6 1-[5-(tert-butyl-diphenyl-silanyloxymethyl)-3-fluoro-4-hydroxy-tetrahydro-thiophen-2-yl]-5-ethyl-4-hydroxy-1H-pyrimidin-2-one 
• 15176-29-1 edoxudine 
• 136160-29-7 5-ethyl-1-ethoxymethyl-6-(benzyl)uracil 
• 25692-02-8 2',3',5'-tri-O-benzoyl-5-ethyluridine 
• 1613530-28-1 C₃₂H₂₉N₃O₈ 
• 1613530-27-0 C₃₄H₂₉N₅O₈ 
• 1365628-57-4 C₁₇H₁₇BrN₂O₄ 
• 1354826-88-2 C₂₄H₂₂N₂O₄ 

Relevant articles and documents

PYRIMIDO COMPOUNDS HAVING ANTIPROLIFERATIVE ACTIVITY (II)

Disclosed are novel pyrimido compounds of the formula (I) wherein R1 to R9 are as defined in the specification, that are selective inhibitors of the Src family of tyrosine kinases. These compounds and their pharmaceutically acceptable salts are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, hepatic and pancreatic tumors. Also disclosed are pharmaceutical compositions containing these compounds and the use for treating cancer.

4'-substituted nucleosides

Nucleosides compounds of Formula I: STR1 wherein B is a purine or a pyrimidine; X and X' are H; Y is H; Y' is OH, F or H; or Y' and X' together makes a bond; Z is STR2 where n is zero, one, two or three; or Y' and Z together form a cyclic phosphate ester; Z' is --CN, --CH3, CH2 N3 or --CH2 J, where J is a halogen atom; or Z' and Y' together are --CH2 O--; and pharmaceutically acceptable esters, ethers, amides, N-acyl moieties and salts thereof.

SYNTHESIS OF 5-ALKYL SUBSTITUTED URACIL DERIVATIVES FROM BARBITURIC ACID

A new two step synthesis of 5-alkyluracil derivatives from barbituric acids is described.Regioselective mono O-mesylation of barbituric acids, followed by desulfonylation under reductive conditions, afforded uracils in high overall yield.The reductive desulfonylation step is also discussed.