42122-41-8

Basic information

• Product Name: alpha-methylpyrrolidine-1-ethanol
• Synonyms: alpha-methylpyrrolidine-1-ethanol;α-Methyl-1-pyrrolidineethanol;1-pyrrolidin-1-ylpropan-2-ol
• CAS NO: 42122-41-8
• Molecular Formula: C₇H₁₅NO
• Molecular Weight: 129.2001
• EINECS: 255-665-1
• Mol File: 42122-41-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 199.6°Cat760mmHg
• Flash Point: 81.9°C
• Appearance: /
• Density: 0.98g/cm³
• CAS DataBase Reference: alpha-methylpyrrolidine-1-ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: alpha-methylpyrrolidine-1-ethanol(42122-41-8)
• EPA Substance Registry System: alpha-methylpyrrolidine-1-ethanol(42122-41-8)

Safety Data

• Hazardous Substances Data: 42122-41-8(Hazardous Substances Data)

Upstream product

• 7335-07-1 N-propylpyrrolidine 
• 123-75-1 pyrrolidine 
• 57-55-6 propylene glycol 
• 75-56-9 methyloxirane 
• 127-00-4 1-Chloro-2-propanol 

Downstream Products

• 575467-04-8 diphenyl-acetic acid-(β-pyrrolidino-isopropyl ester) 

Relevant articles and documents

FUSED 1,4-DIHYDRODIOXIN DERIVATIVES AS INHIBITORS OF HEAT SHOCK TRANSCRIPTION FACTOR 1

The present invention relates to compounds of formula I wherein A1, A2 R4 and Q are as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.

Hydrophobic amplification of noncovalent organocatalysis

The effects of hydrogen-bonding organocatalysts and water for the acceleration of epoxide openings with a variety of nucleophiles are additive and lead to excellent yields of the catalyzed reactions in water. The Royal Society of Chemistry 2006.

N-Alkylation d'amines en catalyse homogene. Synthese de mono- et de diamines cycliques

Ruthenium compounds are appropriate catalysts in the N-alkylation of amines.The synthesis of N-alkylated cyclic amines from a cyclic amine and an alcohol or via the condensation between a diol and a primary amine are described.The reaction with cyclic amines is highly selective, especially in the presence of a phosphine, making it a high yielding preparative procedure.The catalytic condensation between cyclic amines and diols yields either an aminoalcohol (A) or a bicyclic diamine (B).The temperature, the presence of phosphine, and the ratio of amine to diol are decisive in directing the reaction toward A or B.The proposed mechanism involves the dehydrogenation of the alcohol followed by attack of the amine on the aldehyde intermediate.