42155-08-8 Usage
Description
2'-Deoxyuridine 5'-monophosphate disodium salt is a nucleoside analog that functions as an inhibitor of DNA and RNA synthesis by blocking the enzyme thymidylate synthase, which is crucial for the conversion of deoxyuridine 5'-triphosphate into thymidine 5'-monophosphate (dTMP). 2'-Deoxyuridine 5'-monophosphate disodium salt has demonstrated efficacy in the treatment of squamous cell cancer and hyperproliferative diseases such as chronic myelogenous leukemia. Additionally, it exhibits antiviral properties against HIV, herpes simplex virus, and varicella zoster virus.
Uses
Used in Oncology:
2'-Deoxyuridine 5'-monophosphate disodium salt is utilized as a chemotherapeutic agent for the treatment of squamous cell cancer and hyperproliferative diseases like chronic myelogenous leukemia. Its mechanism of action involves the inhibition of DNA synthesis by blocking the enzyme thymidylate synthase, thereby disrupting the formation of dTMP and hindering cancer cell proliferation.
Used in Antiviral Therapy:
In the field of antiviral treatment, 2'-Deoxyuridine 5'-monophosphate disodium salt serves as an agent against various viruses, including HIV, herpes simplex virus, and varicella zoster virus. Its antiviral activity is attributed to its ability to interfere with the synthesis of viral DNA and RNA, thereby inhibiting viral replication and spread.
Used in Research and Development:
2'-Deoxyuridine 5'-monophosphate (dUMP) is employed as a reference substrate in studies investigating the potential of dUMP analogues in chemotherapy applications. This role is instrumental in advancing the understanding of nucleoside analogs and their therapeutic implications in cancer treatment and antiviral therapy.
Biochem/physiol Actions
2′-Deoxyuridine 5′-monophosphate disodium salt (dUMP) conversion to pyrimidine is inhibited by methotrexate. The inhibition of dUMP to deoxythymidine monophosphate (dTMP) at the methylation step is a key in controlling bacterial and eukaryotic cell growth.
Check Digit Verification of cas no
The CAS Registry Mumber 42155-08-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,1,5 and 5 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 42155-08:
(7*4)+(6*2)+(5*1)+(4*5)+(3*5)+(2*0)+(1*8)=88
88 % 10 = 8
So 42155-08-8 is a valid CAS Registry Number.
