421553-62-0Relevant articles and documents
A tryptophan-based copper(ii) coordination polymer: catalytic activity towards Suzuki-Miyaura cross-coupling reactions
Bhasin, K. K.,Husain, Ahmad,Kumar, Girijesh,Kumar, Rakesh,Nar, Kuldeep Kaur,Rani, Pooja,Singh, Amit Pratap
, p. 7855 - 7864 (2021/12/02)
Herein, we report the synthesis and crystal structure determination of a new Cu(ii) coordination polymer (CP) with the formula [Cu(l-tryp)(azpy)1/2(H2O)(NO3)]∝ (CP1), which exhibits an unusual tryptophan coordination mode with copper(ii) via carboxylate monodentate binding as well as chelation via Namino and Ocarbonyl groups. CP1 was prepared using the ligand l-tryptophan (l-tryp) and the co-ligand 4,4′-azopyridine (azpy), adapting the mixed-ligand approach and a solvothermal protocol. Single crystal X-ray structural analysis revealed that in CP1, Cu(ii) sites show a distorted octahedral geometry, wherein the ligand l-tryp is coordinated through the carboxylate and amine groups, whereas the co-ligand azpy is coordinated to Cu(ii) ions through the Npyridyl atom and thus maintains a distorted octahedral geometry around the Cu(ii) ions. FT-IR and EPR spectra were also recorded to corroborate the structural analysis. Finally, CP1 was employed as a heterogeneous catalyst for the Suzuki cross-coupling reaction and afforded ～98% yield under normal reaction conditions. This journal is
The Discovery of Novel ACA Derivatives as Specific TRPM2 Inhibitors that Reduce Ischemic Injury Both in Vitro and in Vivo
Zhang, Han,Yu, Peilin,Lin, Hongwei,Jin, Zefang,Zhao, Siqi,Zhang, Yi,Xu, Qingxia,Jin, Hongwei,Liu, Zhenming,Yang, Wei,Zhang, Liangren
, p. 3976 - 3996 (2021/05/04)
The transient receptor potential melastatin 2 (TRPM2) channel is associated with ischemia/reperfusion injury, inflammation, cancer, and neurodegenerative diseases. However, the limit of specific inhibitors impedes the development of TRPM2-targeted therapeutic agents. To discover more potent and selective TRPM2 inhibitors, 59 N-(p-amylcinnamoyl) anthranilic acid (ACA) derivatives were synthesized and evaluated using calcium imaging and electrophysiology approaches. Systematic structure-activity relationship studies resulted in some potent compounds inhibiting the TRPM2 channel with sub-micromolar half-maximal inhibitory concentration values. Among them, the preferred compound A23 exhibited TRPM2 selectivity over TRPM8 and TRPV1 channels as well as phospholipase A2 and showed neuroprotective activity in vitro. Following pharmacokinetic studies, A23 was further evaluated in a transient middle cerebral artery occlusion model in vivo, which significantly reduced cerebral infarction. These data indicate that A23 might serve as a useful tool for TRPM2-related research as well as a lead compound for the development of therapeutic agents for ischemic injury.
Droplet-based Continuous Flow Synthesis of Palladium Supported on Reduced Graphene Oxide
Jang, Yea Seul,Lee, Jihoon,Nam, Su Min,Park, Chan Pil,Son, Go Eun
, p. 374 - 377 (2020/01/28)
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