4219-46-9

Basic information

• Product Name: 2-hydroxyethyl butyrate
• Synonyms: 2-hydroxyethyl butyrate;Butyric acid 2-hydroxyethyl ester;Ethylene glycol 1-butyrate;Ethylene glycol monobutyrate
• CAS NO: 4219-46-9
• Molecular Formula: C₆H₁₂O₃
• Molecular Weight: 132.15768
• EINECS: 224-158-7
• Mol File: 4219-46-9.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 218°Cat760mmHg
• Flash Point: 89.5°C
• Appearance: /
• Density: 1.027g/cm³
• Vapor Pressure: 0.0274mmHg at 25°C
• Refractive Index: 1.429
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-hydroxyethyl butyrate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxyethyl butyrate(4219-46-9)
• EPA Substance Registry System: 2-hydroxyethyl butyrate(4219-46-9)

Safety Data

• Hazardous Substances Data: 4219-46-9(Hazardous Substances Data)

Usage

General Description

2-Hydroxyethyl butyrate, also known as butyric acid 2-hydroxyethyl ester, is an organic compound that belongs to the class of hydroxy compounds and carboxylic acid esters. It is commonly used as a flavoring ingredient in the food industry and as a fragrance ingredient in the cosmetic and personal care products industry. This chemical is a clear, colorless liquid with a mild, pleasant odor. It is soluble in water and most organic solvents. 2-Hydroxyethyl butyrate is generally recognized as safe (GRAS) for use in food and is considered to have low acute toxicity. It is also used as a solvent and intermediate in the production of other chemicals.

InChI:InChI=1/C6H12O3/c1-2-3-6(8)9-5-4-7/h7H,2-5H2,1H3

Upstream product

• 105-72-6 ethylene glycol dibutyrate 
• 123-20-6 vinyl n-butyrate 
• 107-21-1 ethylene glycol 
• 123-72-8 butyraldehyde 
• 141-75-3 butyryl chloride 
• 111-76-2 2-Butoxyethanol 
• 187737-37-7 propene 
• 201230-82-2 carbon monoxide 
• 66822-97-7 2-methoxy-2-propyl-1,3-dioxolane 
• 75-21-8 oxirane 
• 107-92-6 butyric acid 
• 589-39-9 potassium n-butyrate 
• 107-07-3 2-chloro-ethanol 

Downstream Products

• 1356550-42-9 2-(butyryloxy)ethyl 4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-ylcarbamoyl)benzoate 
• 107-21-1 ethylene glycol 
• 107-92-6 butyric acid 
• 39616-02-9 1-Butyryloxy-2-benzoyloxy-ethan 
• 105-72-6 ethylene glycol dibutyrate 
• 109-21-7 butyl butyrate 

Relevant articles and documents

CYCLIC ORTHO ESTER FUEL ADDITIVE

The invention relates to liquid hydrocarbons containing cyclic ortho esters as dehydrating dehydrating icing inhibitors and to methods of using the compounds. The liquid hydrocarbons include fuels such aviation fuels, lubricants, hydraulic fluids and hydrocarbon solvents.

Rational engineering of Candida antarctica lipase B for selective monoacylation of diols

The enzyme Candida antarctica lipase B was subjected to site directed mutagenesis suggested by molecular modelling. The selectivity for the enzyme increased towards a range of diols over their corresponding monoesters as an effect of the mutations. This journal is The Royal Society of Chemistry 2012.

Kinetics and quantitative structure-activity relationships for pseudomonas sp. Lipase-catalyzed hydrolysis of both monoesters and diesters of ethylene glycol

The goal of this work is to study kinetics and quantitative structure-activity relationships for steady states of Pseudomonas sp. lipase-catalyzed hydrolysis of both diesters and monoesters of ethylene glycol. Based on the steady-state kinetics of the enzyme-catalyzed hydrolysis of the diesters of ethylene glycol, the diesters and the monoesters react simultaneously as soon as monoester has started to build up in the reaction medium. In other words, the apparent Km values of the diesters are the Km values of the diesters (KmA) plus the Km values of the monoesters (KmB), and all Vmax values are about the same. Moreover, the pH-stat titration curve of the enzyme-catalyzed hydrolysis of the diesters of ethylene glycol is initially hyperbolic, then there is a sharp falloff in the hydrolysis rate. The abrupt stoppage of the reaction (relaxation stage) may be due to the existence of two phases in the reaction medium, that is, the product (ethylene glycol) and the substrates (the diesters of ethylene glycol) are not miscible. Furthermore, quantitative structure-activity relationships for varied acyl groups of mono- and diesters of ethylene glycol are studied. The fact that both pKmA and pK mB values are linearly correlated with the hydrophobicity constant (π) but not with the electronic substituent constants (σ*) indicates that the affinity of these substrates for the enzyme depends only on the hydrophobicitv of substrates. Copyright