4219-47-0

Basic information

• Product Name: 2-hydroxyethyl octanoate
• Synonyms: Poly(oxy-1,2-ethanediyl), alpha-(1-oxooctyl)-omega-hydroxy-
• CAS NO: 4219-47-0
• Molecular Formula: C₁₀H₂₀O₃
• Molecular Weight: 188.264
• Mol File: 4219-47-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 288°C at 760 mmHg
• Flash Point: 114.7°C
• Density: 0.967g/cm³
• Vapor Pressure: 0.000267mmHg at 25°C
• Refractive Index: 1.443
• CAS DataBase Reference: 2-hydroxyethyl octanoate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxyethyl octanoate(4219-47-0)
• EPA Substance Registry System: 2-hydroxyethyl octanoate(4219-47-0)

Safety Data

• Hazardous Substances Data: 4219-47-0(Hazardous Substances Data)

Upstream product

• 124-12-9 caprylnitrile 
• 107-21-1 ethylene glycol 
• 111-64-8 n-octanoic acid chloride 
• 124-07-2 Octanoic acid 
• 627-86-1 1,2-di-O-octanoyl-ethylene-glycerol 
• 107-07-3 2-chloro-ethanol 
• 4359-57-3 2-heptyl-1,3-dioxolane 
• 497-26-7 2-methyl-1,3-dioxolane 

Downstream Products

• 124-07-2 Octanoic acid 
• 107-21-1 ethylene glycol 

Relevant articles and documents

COMPOSITIONS COMPRISING ENZYME CLEAVABLE LINKER PLATFORMS AND CONJUGATES THEREOF

The present invention relates to a cleavable linker platform. In particular, the invention relates to construction of an enzyme cleavable linker platform conjugated to a drug or a diagnostically relevant compound, a biomolecule, and an enzyme cleavable group, for which cleavage of the enzyme cleavable group leads to release of the drug or diagnostically relevant compound.

Combinatorial synthesis of PEG oligomer libraries

A simple chain-extending approach was established for the scale-up of the monoprotected monodisperse PEG diol materials. Reactions of THP-(OCH2CH2)n—OMs (n=4, 8, 12) with a large excess of commercially available H—(OCH2CH2)n—OH (n=1-4) under basic conditions led to THP-(OCH2CH2)n—OH (n=5-15). Similarly, Me-(OCH2CH2)n—OH (n=4-11, 13) were prepared from Me-(OCH2CH2)n—OMs (n=3, 7, 11). For the chain elongation steps, 40-80% yields were achieved through extraction purification. PEG oligomer libraries I and II were generated in 50-95% overall yields by alkylation or acylation of THP-(OCH2CH2)n—OH (n=1-15) followed by deprotection. Alkylation of Me-(OCH2CH2)n—OH (n=1-11, 13) with X—(CH2)m—CO2R (X=Br or OMs) and subsequent hydrolysis led to PEG oligomer library III in 30-60% overall yields. Combinatorial purification techniques were adapted to the larger-scale library synthesis. A total of 498 compounds, each with a weight of 2-5 g and a minimum purity of 90%, were synthesized.

Cobalt(II) catalyzed oxidation of 2-substituted 1,3-dioxolanes with molecular oxygen

Cobalt(II) chloride catalyzed oxidation of 2-substituted 1,3-dioxolanes in 1,2-dimethoxyethane afforded formate esters and acids in high yields.Is was found that the presence of catalytic amounts of ZnCl2 increased the rate of oxidation.A free-radical mechanism is proposed, involving participation of superoxocobalt, and the esterification of the alcohol and acid.