42205-73-2

Basic information

• Product Name: 4-tert-Butylpyridine-2-carbonitrile
• Synonyms: 4-tert-Butylpyridine-2-carbonitrile;2-Pyridinecarbonitrile, 4-(1,1-diMethylethyl)-
• CAS NO: 42205-73-2
• Molecular Formula: C10H12N2
• Molecular Weight: 160
• Mol File: 42205-73-2.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-tert-Butylpyridine-2-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-tert-Butylpyridine-2-carbonitrile(42205-73-2)
• EPA Substance Registry System: 4-tert-Butylpyridine-2-carbonitrile(42205-73-2)

Safety Data

• Hazardous Substances Data: 42205-73-2(Hazardous Substances Data)

Usage

General Description

4-tert-Butylpyridine-2-carbonitrile, also known as 4-tert-Butyl-2-cyanopyridine, is a chemical compound with the molecular formula C12H14N2. It is a pyridine derivative containing a cyano group and a tert-butyl substituent, making it a highly stable and hydrophobic molecule. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It is produced by the reaction of 4-tert-butylpyridine with a suitable cyanogen halide reagent. 4-tert-Butylpyridine-2-carbonitrile has the potential to be a versatile building block for the development of new organic compounds due to its unique structure and reactivity. However, it is important to handle this chemical with care, as it may present potential health and environmental hazards.

Upstream product

• 23569-17-7 4-tert-butylpyridine N-oxide 
• 7677-24-9 trimethylsilyl cyanide 
• 151-50-8 potassium cyanide 
• 77-78-1 dimethyl sulfate 
• 3978-81-2 4-tert-butylpyridine 
• 95111-63-0 C₁₀H₁₆NO⁽¹⁺⁾*CH₃O₄S^(1-) 

Downstream Products

• 166897-61-6 N,N'-(4,5-dichloro-o-phenylene)bis(4-tert-butylpyridine-2-carboxamide) 
• 261777-35-9 (2R,4S)-cis-4-(tert-butyl)-1,2-piperidinedicarboxylic acid 1-(phenylmethyl) ester 
• 261777-40-6 (2R,4S)-cis-4-(tert-butyl)-1,2-piperidinedicarboxylic acid 2-methyl 1-(phenylmethyl) diester 
• 261777-43-9 (2S,4S)-trans-4-(tert-butyl)-1,2-piperidinedicarboxylic acid 2-methyl 1-(phenylmethyl) diester 
• 41225-63-2 1-(4-tert-butylpyridin-2-yl)ethanone 
• 42205-74-3 4-tert-Butylpyridine-2-carboxylic acid 
• 123811-75-6 4-tert-Butyl-pyridine-2-carboxylic acid; hydrochloride 

Relevant articles and documents

(4-(([1,2,4]TRIAZOLO[4,3-A]PYRIDINE-6-YL)OXY)-1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL) UREIDO DERIVATIVES AS ANTI-INFLAMMATORY P38 MAPK INHIBITORS FOR TREATING DISEASES OF THE RESPIRATORY TRACT

This invention relates to (4-(([l,2,4]triazolo[4,3-a]pyridine-6-yl) oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido derivatives that are p38 MAPK (mitogen activated protein kinase) inhibitors as antiinflammatory agents for treating diseases of the respirato

Urea-functionalized M4L6 cage receptors: Anion-templated self-assembly and selective guest exchange in aqueous solutions

We present an extensive study of a novel class of de novo designed tetrahedral M4L6 (M = Ni, Zn) cage receptors, wherein internal decoration of the cage cavities with urea anion-binding groups, via functionalization of the organic components L, led to selective encapsulation of tetrahedral oxoanions EO4n- (E = S, Se, Cr, Mo, W, n = 2; E = P, n = 3) from aqueous solutions, based on shape, size, and charge recognition. External functionalization with tBu groups led to enhanced solubility of the cages in aqueous methanol solutions, thereby allowing for their thorough characterization by multinuclear (1H, 13C, 77Se) and diffusion NMR spectroscopies. Additional experimental characterization by electrospray ionization mass spectrometry, UV-vis spectroscopy, and single-crystal X-ray diffraction, as well as theoretical calculations, led to a detailed understanding of the cage structures, self-assembly, and anion encapsulation. We found that the cage self-assembly is templated by EO4n- oxoanions (n ≥ 2), and upon removal of the templating anion the tetrahedral M4L6 cages rearrange into different coordination assemblies. The exchange selectivity among EO4n- oxoanions has been investigated with 77Se NMR spectroscopy using 77SeO42- as an anionic probe, which found the following selectivity trend: PO 43- ? CrO42- > SO 42- > SeO42- > MoO 42- > WO42-. In addition to the complementarity and flexibility of the cage receptor, a combination of factors have been found to contribute to the observed anion selectivity, including the anions' charge, size, hydration, basicity, and hydrogen-bond acceptor abilities.

METHODS OF TREATMENT OF AMYLOIDOSIS USING ASPARTYL-PROTEASE INHIBITORS

The invention relates to acetyl 2-hydroxy-1,3-diaminospirocyclohexanes and derivatives thereof that are useful in treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.