4230-26-6Relevant articles and documents
4,7-disubstituted 7h-pyrrolo[2,3-d]pyrimidines and their analogs as antiviral agents against zika virus
Chen, Liqiang,Geraghty, Robert J.,Jung, Eunkyung,Qiu, Li,Soto-Acosta, Ruben,Wilson, Daniel J.
, (2021/07/09)
Discovery of compound 1 as a Zika virus (ZIKV) inhibitor has prompted us to investigate its 7H-pyrrolo[2,3-d]pyrimidine scaffold, revealing structural features that elicit antiviral activity. Furthermore, we have demonstrated that 9H-purine or 1H-pyrazolo[3,4-d]pyrimidine can serve as an alternative core structure. Overall, we have identified 4,7-disubstituted 7H-pyrrolo[2,3-d]pyrimidines and their analogs including compounds 1, 8 and 11 as promising antiviral agents against flaviviruses ZIKV and dengue virus (DENV). While the molecular target of these compounds is yet to be elucidated, 4,7-disubstituted 7H-pyrrolo[2,3-d]pyrimidines and their analogs are new chemotypes in the design of small molecules against flaviviruses, an important group of human pathogens.
Purine N-alkylated derivatives. SRN1 synthesis and functional group transformations
Gharbaoui, Tawfik,Benhida, Rachid,Chastanet, Jacqueline,Lechevallier, Andre,Maillos, Philippe,Beugelmans, Rene
, p. 561 - 574 (2007/10/02)
Purine and its 6-chloro, 6-methoxy, 6-amino and 2-amino-6-chloro derivatives are efficient nucleophiyles in SRN1 reactions with various functionalized gem halo-nitroalkanes as substrates in which good regioselectivity on N9 is observ