4240-97-5

Basic information

• Product Name: 1,2-DIHYDRO-4-METHYL-2-OXO-6-PHENYLPYRIDINE-3-CARBONITRILE
• Synonyms: SALOR-INT L232769-1EA;4-METHYL-2-OXO-6-PHENYL-1,2-DIHYDRO-3-PYRIDINECARBONITRILE;1,2-DIHYDRO-4-METHYL-2-OXO-6-PHENYLPYRIDINE-3-CARBONITRILE
• CAS NO: 4240-97-5
• Molecular Formula: C₁₃H₁₀N₂O
• Molecular Weight: 210.23
• Mol File: 4240-97-5.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,2-DIHYDRO-4-METHYL-2-OXO-6-PHENYLPYRIDINE-3-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-DIHYDRO-4-METHYL-2-OXO-6-PHENYLPYRIDINE-3-CARBONITRILE(4240-97-5)
• EPA Substance Registry System: 1,2-DIHYDRO-4-METHYL-2-OXO-6-PHENYLPYRIDINE-3-CARBONITRILE(4240-97-5)

Safety Data

• Hazardous Substances Data: 4240-97-5(Hazardous Substances Data)

Usage

Chemical Class

Pyridine derivative

Usage

Organic synthesis and medicinal chemistry

Potential Applications

Antiviral and antitumor agent

Chemical Structure

Pyridine ring
Methyl group (-CH3) as a substituent
Carbonyl group (C=O) as a substituent
Phenyl group (C6H5) as a substituent
Nitrile group (C≡N) as a substituent

Nitrile Group

Makes the compound potentially useful for further chemical modifications to develop new drugs or biologically active compounds.

Upstream product

• 105-56-6 ethyl 2-cyanoacetate 
• 93-91-4 1-phenylbutan-1,3-dione 
• 109-77-3 malononitrile 
• 23652-90-6 3-amino-1-phenylbut-2-en-1-one 
• 107-91-5 cyanoacetic acid amide 
• 77252-92-7 3-ethoxy-1-phenyl-but-2-en-1-one 
• 98-86-2 acetophenone 
• 33951-43-8 3-hydroxy-1-phenyl-but-2-en-1-one 
• 74152-13-9 6-methyl-1,4-diphenylpyrimidin-2(1H)-one 
• 41808-21-3 sodium salt of α-cyanoacetamide 

Downstream Products

• 164664-96-4 4-Methyl-6-phenyl-2-trimethylsilanyloxy-nicotinonitrile 
• 771573-87-6 C₁₃H₁₄N₂O 
• 1413941-36-2 C₂₂H₁₄N₄O₃ 
• 1413941-21-5 C₂₀H₁₃N₃O₂ 
• 1413941-37-3 4-Amino-5-methyl-7-phenyl-1H-pyrido [2,3-d] pyrimidine-2-thione 
• 1413941-26-0 4-amino-5-methyl-7-phenyl-1H-pyrido [2,3-d]pyrimidine-2-one 
• 110060-38-3 5-methyl-7-phenyl-3H-pyrido [2,3-d] pyrimidin-4-one 
• 1413941-25-9 2,5-dimethyl-7-phenyl-3H-pyrido[2,3-d] pyrimidine-4-one 

Relevant articles and documents

Synthesis and luminescent properties and theoretical investigation on electronic structure of nitrile-based 2-pyridone molecules

3-Cyano-4,6-dimethyl-2-pyridone and 3-cyano-4-methyl-6-phenyl-2-pyridone were synthesized effectively by the reaction of readily available 1,3-diketone and malononitrile directly and in good yield. Upon photoexcitation, 3-cyano-4-methyl-6-phenyl-2-pyridone in ethanol shows strong blue emission. The ground- and excited-state geometries, charge distributions, and excitation energies of 2-pyridone derivatives were evaluated by ab initio calculations. Organic light-emitting diodes (OLED) made using 3-cyano-4-methyl-6-phenyl-2- pyridone as dopant showed blue light emission with a maximum electroluminescence (EL) emission at around 456 nm.

Synthesis and Photophysical Properties of 3-Amino-4-arylpyridin-2(1 H)-ones

A method has been developed for the preparation of oxazolo-[5,4- b ]pyridin-2(1 H)-ones based on the Hoffmann reaction of 2-oxo-1,2-dihydropyridine-3-carboxamides. Hydrolysis of oxazolo[5,4- b ]pyridin-2(1 H)-ones and the Hoffmann reaction of 2-oxo-1,2-dihydropyridine-3-carboxamides yielded 3-aminopyridin-2(1 H)-ones, including 4-aryl substituted derivatives in the series, for which effective phosphors with a quantum yield of up to 0.78 were detected. Photophysical properties of 3-aminopyridin-2(1 H)-ones were studied by UV and luminescence spectroscopy methods, and the relationship between their structure and photophysical properties was revealed.

Design and synthesis of 2-pyridone based flexible dimers and their conformational study through X-ray diffraction and density functional theory: Perspective of cyclooxygenase-2 inhibition

This paper describes the results of X-ray crystallography of 4-methyl-2-oxo-6-phenyl-1,2-dihydropyridine-3-carbonitrile (1) and its propylene bridged dimers 2 and 3. Influence of inter- and intramolecular interactions on the conformation of propylene link